EFFECTS OF PYRIDOXINE DEFICIENCY ON AUDIOGENIC SEIZURE SUSCEPTIBILITY IN INBRED MICE.

Abstract

Summary Mice of inbred strains DBA/2J, P/J, BDP/J, C57BL/6J, and F1 hybrid B6D2F1 (C57BL/6J × DBA/2J) mice were maintained on diets containing either 0, 10, or 30 mg of pyridoxine (vitamin B6) per kg of diet. Animals were placed on these diets when 3 to 4 weeks old and maintained on the diets for 7 weeks. Susceptibility to audiogenic seizures was determined 3, 5, and 7 weeks after the mice had been put on these respective dietary regimens. Mice of the dilute strain (homozygous d/d), i.e., strains DBA/2J, BDP/J, and P/J were found to be more susceptible to audiogenic seizures in the pyridoxine deficient state. Body weights were also recorded every 3 to 4 days. Dilute strains (DBA/2J, BDP/J and P/J) and the hybrid B6D2F1 showed smaller increments in body weights on the pyridoxine deficient diets than did C57BL/6J mice.