Distribution of 125J-labeled leucopyrokinin (LPK) in rats.

A Plech, M Rykaczewska-Czerwińska, F Ryszka, A Suszka-Switek, B Dolińska, D Konopińska
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Abstract

The distribution in parts of the brain and internal organs of 125J-labeled leucopyrokinin (LPK), an insect myotropic peptide injected into the lateral brain ventricle was determined in rats. A high accumulation of this peptide in adrenals and in the hypothalamus and hippocampus of the brain was found. A lesser but significant LPK accumulation in other internal organs and parts of the brain was also observed. The significance of this effect for the biological activity of LPK in rats is discussed.

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125j标记的白细胞激肽(LPK)在大鼠体内的分布。
研究了大鼠侧脑室注射125j标记的促肌肽leucoprokinin (LPK)在脑和内脏部分组织中的分布。这种肽在肾上腺、下丘脑和海马体中大量积聚。在其他内脏器官和大脑部分也观察到较少但显著的LPK积累。讨论了该效应对LPK在大鼠体内生物活性的影响。
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