{"title":"INFLUENCE OF HYDRALAZINE ON THE SULFHYDRYL GROUP IN THE PRESENCE OF CUPRIC ION.","authors":"D A GERBER","doi":"10.3181/00379727-119-30108","DOIUrl":null,"url":null,"abstract":"Summary Fifty-one compounds were studied for their ability to compete with the sulfhydryl group for cupric ions. The sulfhydryl-disulfide interchange reactions occurring during the reaction between cysteine and bis (p-nitrophenyl) disulfide and during the course of the denaturation of human serum gamma globulin by heat were used as models for this reaction. Hydralazine, a compound which has been reported to induce a disease resembling systemic lupus erythematosus was exceptionally active in reactivating the sulfhydryl-disulfide interchange reaction when this reaction was studied in the presence of cupric ion.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"100-4"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30108","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Summary Fifty-one compounds were studied for their ability to compete with the sulfhydryl group for cupric ions. The sulfhydryl-disulfide interchange reactions occurring during the reaction between cysteine and bis (p-nitrophenyl) disulfide and during the course of the denaturation of human serum gamma globulin by heat were used as models for this reaction. Hydralazine, a compound which has been reported to induce a disease resembling systemic lupus erythematosus was exceptionally active in reactivating the sulfhydryl-disulfide interchange reaction when this reaction was studied in the presence of cupric ion.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
