Acromegaly and heart failure: revisions of the growth hormone/insulin-like growth factor axis and its relation to the cardiovascular system.

Th B Twickler, M J M Cramer, S P Senden, P A Doevendans, W R de Vries, D W Erkelens, H P F Koppeschaar
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引用次数: 3

Abstract

Cardiomyopathy is a major cause of death in overt acromegaly. Recent progress in research has increasingly revealed the molecular mechanisms concerning growth hormone and insulin-like growth factor in the development of heart failure. In this article, we propose mechanisms according to which heart failure occurs, and we aim to extrapolate this knowledge to more general processes involved in heart failure.

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肢端肥大症和心力衰竭:生长激素/胰岛素样生长因子轴的修正及其与心血管系统的关系。
心肌病是显性肢端肥大症的主要死亡原因。近年来的研究进展越来越多地揭示了生长激素和胰岛素样生长因子在心力衰竭发生发展中的分子机制。在这篇文章中,我们提出了心力衰竭发生的机制,我们的目标是将这些知识推断到心力衰竭的更一般的过程。
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