Dynamic Changes of Regulatory T Cells/CD4⁺ T Cells in Peripheral Blood of Adult Kidney Transplant Recipients: A Comparison of Pediatric and Adult Kidney Donors.

IF 1.1 4区 医学 Q3 SURGERY Annals of Transplantation Pub Date : 2023-09-26 DOI:10.12659/AOT.940604
Qi Xiao, Zide Chen, Shitao Zhao, Kaifeng Luo, Fuping Cao, Zexu Zhang, Jia Liu, Jiansheng Xiao
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Abstract

BACKGROUND Inducing transplantation tolerance and monitoring the recipient's immune status to improve allograft survival remains the main goal for kidney transplantation (KTx). MATERIAL AND METHODS A total of 53 renal transplantation patients and 20 healthy individuals were assigned to the post-transplantation and healthy groups, respectively; 10 recipients with stable renal function for 2 years after kidney transplantation were assigned to Group C. Eleven kidney transplantation recipients were hospitalized due to lung infection. Flow cytometry was used to measure levels of Tregs/CD4⁺ T cells. RESULTS The Tregs/CD4⁺ T cells ratio reached homeostasis 6 months after KTx, with no significant difference between Group D (healthy control group) and pre-surgery or Group C (2 years after KTx group). The pediatric donor group and the adult donor group reached immune homeostasis 3 months after the operation. Immune homeostasis is maintaining a balance between immune tolerance and immunogenicity. There was no significant difference in graft function between the pediatric and adult donor groups before surgery, 1 day after surgery, 1 week after surgery, 2 weeks after surgery, and 1 month after surgery; however, graft function was significantly better in the pediatric donor group compared with the adult donor group at 3 mouths (eGFR: 51.7 (40.4-66.2) vs 73.0 (55.7-90.2), P=0.008<0.05) and 6 months (eGFR: 52.2 (37.5-62.8) vs 80.5 (64.1-90.4), P<0.001) after surgery. Pediatric donor kidneys reached immune homeostasis 3 months after surgery, with better graft function at this time compared with adult donor kidneys. The proportion of Tregs/CD4⁺ T cells in recipients with a pulmonary infection after KTx was lower than in those with infection recovery. CONCLUSIONS Expanding the use of pediatric kidneys should be further explored by the transplantation community. The proportion of Tregs/CD4⁺ T cells in recipients with a pulmonary infection after KTx was lower than in those with infection recovery.

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调节性T细胞/CD4的动态变化⁺ 成人肾移植受者外周血T细胞:儿童和成人供肾者的比较。
背景诱导移植耐受并监测受体的免疫状态以提高同种异体移植物的存活率仍然是肾移植(KTx)的主要目标。材料和方法将53名肾移植患者和20名健康人分别分为移植后组和健康组;10名肾移植后肾功能稳定2年的受试者被分为C组。11名肾移植受试者因肺部感染住院。流式细胞术用于测量Tregs/CD4的水平⁺ T细胞。结果Tregs/CD4⁺ KTx后6个月,T细胞比例达到稳态,D组(健康对照组)与手术前或C组(KTx组后2年)之间无显著差异。儿童供体组和成人供体组在手术后3个月达到免疫稳态。免疫稳态是维持免疫耐受和免疫原性之间的平衡。手术前、术后1天、术后一周、术后2周和术后1个月,儿童和成人供体组的移植物功能没有显著差异;然而,与成人供体组相比,儿童供体组在3口时的移植物功能明显更好(eGFR:51.7(40.4-66.2)vs 73.0(55.7-90.2),P=0.008
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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
79
审稿时长
>12 weeks
期刊介绍: Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
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