Investigation of tumor assessment between two PET systems using various indices: comparison between PET/CT and PET/MRI systems.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2023-08-15 eCollection Date: 2023-01-01

Hirotoshi Hotsumi, Shirou Ishii, Hiroki Suenaga, Shigeyasu Sugawara, Kenji Fukushima, Hiroshi Ito

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Abstract

This study aimed to determine the comparability of tumor-uptake indices of ¹⁸F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of ¹⁸F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUV_max and SUV_peak, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with margin thresholds of SUV of 50% (MTV_50%; TLG_50%, respectively) were measured as indices for comparison of measurements in tumors. Comparative indices with tumor SUV_max and liver ratio (TLR_max), brain ratio (TBR_max) were calculated. These indices were compared between PET/CT and PET/MRI examinations. The data measured using PET/CT and PET/MRI showed significant correlations for all tumor indices. The correlation was strongest for SUV_peak (r = 0.933), followed by TBR_max (r = 0.929); and the index ratio of (PET/CT)/(PET/MRI) data was close to 1.0 for TLR_max (1.00 ± 0.22) and TBR_max (1.01 ± 0.21), followed by MTV_50% (0.82 ± 0.33) and TLG_50% (1.18 ± 0.45). The values of all indices showed strong correlations between PET/CT and PET/MRI examinations. Among them, TLR_max, TBR_max, MTV_50%, and TLG_50% showed a close value and may be useful for comparison of tumor evaluation between two PET systems.

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使用不同指标在两种PET系统之间进行肿瘤评估的研究：PET/CT和PET/MRI系统之间的比较。

本研究旨在确定18F-FDG在正电子发射断层扫描/计算机断层扫描（PET/CT）和正电子发射断层摄影/磁共振成像（PET/MRI）中的肿瘤摄取指数的可比性。对55例原发性恶性肿瘤患者进行了2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）PET/CT和PET/MRI检查。在所有检查中，PET/CT均先于PET/MRI。测定18F-FDG在病变和正常器官（脑、肝）中的积聚。测量最大和峰值标准化摄取值（SUV；分别为SUVmax和SUVpeak）、代谢肿瘤体积（MTV）和总损伤糖酵解（TLG），SUV的边缘阈值为50%（分别为MTV50%和TLG50%），作为比较肿瘤测量的指标。计算肿瘤SUVmax与肝比值（TLRmax）、脑比值（TBRmax）的比较指标。这些指标在PET/CT和PET/MRI检查之间进行了比较。使用PET/CT和PET/MRI测量的数据显示出所有肿瘤指标的显著相关性。SUVpeak的相关性最强（r=0.933），其次是TBRmax（r=0.929）；TLRmax（1.00±0.22）和TBRmax（1.01±0.21）的（PET/CT）/（PET/MRI）数据的指数比接近1.0，其次是MTV50%（0.82±0.33）和TLG50%（1.18±0.45）。其中，TLRmax、TBRmax、MTV50%和TLG50%显示出相近的值，并且可能有助于比较两种PET系统之间的肿瘤评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.