Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-19 DOI:10.1007/s10522-023-10066-7
Mariano Almirón, Federico H Gomez, Pablo Sambucetti, Fabian M Norry
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Abstract

Heat-induced hormesis in longevity is the increase in life span resulting from the previous exposure to a mild heat stress early in life. Here we examined heat-induced hormesis of Drosophila buzzatii in five mass-mating populations, which were derived from five wild populations along an elevation gradient from 202 to 1855 m above sea level in North-Western Argentina. Five day old flies were exposed to 37.5 °C for 90 min to induce hormesis and its possible variation across altitudinal populations. This heat treatment strongly extended longevity in lowland-derived flies from the most heat-resistant population only. Both heat-induced effects on longevity and heat-knockdown time (heat-stress sensitivity) were negatively correlated to altitude of population of origin. Hormesis was positively correlated to heat-knockdown time across populations. These results indicate that variation in heat-induced hormesis can not be considered as independent of heat-stress sensitivity (or heat-knockdown time) in populations of insects.

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热诱导的长寿兴奋症与来自不同海拔高度的果蝇实验室种群的热应激敏感性有关。
寿命中的热致兴奋是指由于早期暴露于轻度热应激而导致的寿命延长。在这里,我们在五个大规模交配种群中检测了热诱导的嗡嗡果蝇的兴奋,这些种群来自阿根廷西北部海拔202至1855米的五个野生种群。将5天大的苍蝇暴露在37.5°C下90分钟,以诱导兴奋及其在不同海拔种群中的可能变化。这种热处理大大延长了低地苍蝇的寿命,这些苍蝇只来自最耐热的种群。热诱导对寿命和热击倒时间(热应激敏感性)的影响均与原籍人口的海拔高度呈负相关。不同人群的荷尔蒙分泌与体温下降时间呈正相关。这些结果表明,在昆虫种群中,热诱导的兴奋性变化不能被认为与热应激敏感性(或热击倒时间)无关。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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