Increased expression of leucine-rich α-2 glycoprotein 1 as a predictive biomarker of favorable progression-free survival in meningioma.

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Neuropathology Pub Date : 2024-04-01 Epub Date: 2023-09-25 DOI:10.1111/neup.12944
Mayuko Moritsubo, Takuya Furuta, Junko Miyoshi, Satoru Komaki, Kiyohiko Sakata, Hiroaki Miyoshi, Motohiro Morioka, Koichi Ohshima, Yasuo Sugita
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Abstract

Most meningiomas, which are frequent central nervous system tumors, are classified as World Health Organization (WHO) grade 1 because of their slow-growing nature. However, the recurrence rate varies and is difficult to predict using conventional histopathological diagnoses. Leucine-rich α-2 glycoprotein 1 (LRG1) is involved in cell signal transduction, cell adhesion, and DNA repair and is a predictive biomarker in different malignant tumors; however, such a relationship has not been reported in meningiomas. We examined tissue microarrays of histological samples from 117 patients with grade 1 and 2 meningiomas and assessed their clinical and pathological features, including expression of LRG1 protein. LRG1-high meningiomas showed an increased number of vessels with CD3-positive cell infiltration (P = 0.0328) as well as higher CD105-positive vessels (P = 0.0084), as compared to LRG1-low cases. They also demonstrated better progression-free survival (hazard ratio [HR] 0.11, 95% confidence interval [CI] 0.016-0.841) compared to LRG1-low patients (P = 0.033). Moreover, multivariate analysis indicated that high LRG1 expression was an independent prognostic factor (HR, 0.13; 95% CI, 0.018-0.991; P = 0.049). LRG1 immunohistochemistry may be a convenient tool for estimating the prognosis of meningiomas in routine practice. Further studies are required to elucidate the key role of LRG1 in meningioma progression.

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富含亮氨酸的α-2糖蛋白1的表达增加,作为脑膜瘤无进展生存率的预测生物标志物。
大多数脑膜瘤是常见的中枢神经系统肿瘤,由于其生长缓慢,被列为世界卫生组织(世界卫生组织)一级。然而,复发率各不相同,使用传统的组织病理学诊断很难预测。富含亮氨酸的α-2糖蛋白1(LRG1)参与细胞信号转导、细胞粘附和DNA修复,是不同恶性肿瘤的预测性生物标志物;然而,这种关系在脑膜瘤中还没有报道。我们检查了117名1级和2级脑膜瘤患者的组织学样本的组织微阵列,并评估了他们的临床和病理特征,包括LRG1蛋白的表达。LRG1高脑膜瘤CD3阳性细胞浸润的血管数量增加(P = 0.0328)及CD105阳性血管数较高(P = 0.0084)。与LRG1低水平患者相比,他们也表现出更好的无进展生存率(风险比[HR]0.11,95%置信区间[CI]0.016-0.841)(P = 0.033)。此外,多变量分析表明LRG1高表达是一个独立的预后因素(HR,0.13;95%CI,0.018-0.991;P = 0.049)。LRG1免疫组织化学可能是在常规实践中评估脑膜瘤预后的一种方便的工具。需要进一步的研究来阐明LRG1在脑膜瘤进展中的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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