Objective detection of visual field defects with multifrequency VEPs.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Documenta Ophthalmologica Pub Date : 2024-02-01 Epub Date: 2023-09-26 DOI:10.1007/s10633-023-09949-4

Katja Crux, Cord Huchzermeyer, Jan Kremers, Folkert K Horn

{"title":"Objective detection of visual field defects with multifrequency VEPs.","authors":"Katja Crux, Cord Huchzermeyer, Jan Kremers, Folkert K Horn","doi":"10.1007/s10633-023-09949-4","DOIUrl":null,"url":null,"abstract":"Purpose: To correlate multifrequency pattern reversal VEPs in quadrants (QmfrVEPs) with perimetric field losses for objective detection of visual field losses.Methods: QmfrVEP measurements were performed using four LED-based checkerboard stimulators to stimulate the four quadrants of the visual field. QmfrVEPs were measured monocularly in 5 normal subjects and in 5 glaucoma patients who showed losses in conventional Octopus perimetry. The pattern reversal frequency varied slightly between the stimulators: (11.92, 12.00, 12.08 and 12.16 reversals/sec). The responses to the different stimuli were identified by discrete Fourier analysis. VEPs were recorded using different electrode configurations, and the recording with the highest signal-to-noise ratio (SNR) was used for further analysis.Results: QmfrVEP responses from the different quadrants can be reliably measured and separated using the 0.08 reversals/sec interstimulus reversal frequency differences. The signal-to-noise ratio in the four quadrants was significantly correlated with the equivalent visual field losses obtained with perimetry (Spearman rank correlation: P < 0.001). In the five glaucoma patients, the SNR was reduced in 15 out of the 16 quadrants with a perimetric defect, in comparison to the results in quadrants of healthy subjects. This confirms the sensitivity of the procedure.Conclusion: QmfrVEP responses can be measured reliably. This pilot study suggests that high SNR values exclude visual field defects and that focal defects can be identified in glaucoma patients.Trial registration: www.Clinicaltrials: gov . NCT00494923.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"15-24"},"PeriodicalIF":2.6000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10879258/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Documenta Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10633-023-09949-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To correlate multifrequency pattern reversal VEPs in quadrants (QmfrVEPs) with perimetric field losses for objective detection of visual field losses.

Methods: QmfrVEP measurements were performed using four LED-based checkerboard stimulators to stimulate the four quadrants of the visual field. QmfrVEPs were measured monocularly in 5 normal subjects and in 5 glaucoma patients who showed losses in conventional Octopus perimetry. The pattern reversal frequency varied slightly between the stimulators: (11.92, 12.00, 12.08 and 12.16 reversals/sec). The responses to the different stimuli were identified by discrete Fourier analysis. VEPs were recorded using different electrode configurations, and the recording with the highest signal-to-noise ratio (SNR) was used for further analysis.

Results: QmfrVEP responses from the different quadrants can be reliably measured and separated using the 0.08 reversals/sec interstimulus reversal frequency differences. The signal-to-noise ratio in the four quadrants was significantly correlated with the equivalent visual field losses obtained with perimetry (Spearman rank correlation: P < 0.001). In the five glaucoma patients, the SNR was reduced in 15 out of the 16 quadrants with a perimetric defect, in comparison to the results in quadrants of healthy subjects. This confirms the sensitivity of the procedure.

Conclusion: QmfrVEP responses can be measured reliably. This pilot study suggests that high SNR values exclude visual field defects and that focal defects can be identified in glaucoma patients.

Trial registration: www.

Clinicaltrials: gov . NCT00494923.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

多频VEP对视野缺陷的客观检测。

目的：将象限中的多频模式反转VEP（QmfrVEP）与周边视野损失相关联，以客观检测视野损失。方法：使用四个基于LED的棋盘刺激器对视野的四个象限进行QmfrVEP测量。对5名正常受试者和5名在常规章鱼视野测量中出现损失的青光眼患者进行单目测量QmfrVEP。刺激器之间的模式反转频率略有变化：（11.92、12.00、12.08和12.16反转/秒）。通过离散傅立叶分析来识别对不同刺激的反应。使用不同的电极配置记录VEP，并使用具有最高信噪比（SNR）的记录进行进一步分析。结果：来自不同象限的QmfrVEP反应可以可靠地测量和分离，使用0.08的反转/秒间隙反转频率差。四个象限的信噪比与视野测量获得的等效视野损失显著相关（Spearman秩相关：P 结论：QmfrVEP反应可以可靠地测量。这项初步研究表明，高信噪比值排除了视野缺陷，青光眼患者可以发现局灶性缺陷。试验注册：www.Clinicaltrials.gov。NCT00494923。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).