Regulation of microRNA by circular RNA.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-10-02 DOI:10.1002/wrna.1820
Suman Singh, Tanvi Sinha, Amaresh C Panda
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Abstract

Circular (circ)RNAs have emerged as novel regulators of gene expression through various mechanisms. However, most publications focus on functional circRNAs regulating target gene expression by interacting with micro (mi)RNAs and acting as competing endogenous RNAs (ceRNAs). Although the theory of miRNA sponging by ceRNAs suggests the inhibition of miRNA activity, many studies are biased toward the selection of miRNAs showing a reverse expression pattern compared with circRNA expression. Although several computational tools and molecular assays have been used to predict and validate the interaction of miRNAs with circRNAs, the actual validation of functional in vivo interactions needs careful consideration of molecular experiments with specific controls. As extensive research is being performed on circRNA, many questions arise on the functional significance of circRNA-miRNA interactions. We hope the critical discussion on the criteria for selecting circRNA-miRNA pairs for functional analysis and providing standard methods for validating circRNA-miRNA interactions will advance our understanding of circRNAs as novel gene regulators. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs Translation > Regulation RNA Methods > RNA Analyses in Cells.

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环状核糖核酸对微小核糖核酸的调节。
环状(circ)RNA已通过各种机制成为基因表达的新调节因子。然而,大多数出版物关注的是通过与微小(mi)RNA相互作用并作为竞争性内源性RNA(ceRNA)来调节靶基因表达的功能性circRNA。尽管ceRNA吸收miRNA的理论表明miRNA活性受到抑制,但许多研究倾向于选择与circRNA表达相比表现出反向表达模式的miRNA。尽管已经使用了几种计算工具和分子分析来预测和验证miRNA与circRNA的相互作用,但体内功能相互作用的实际验证需要仔细考虑具有特定对照的分子实验。随着对circRNA的广泛研究,circRNA-miRNA相互作用的功能意义出现了许多问题。我们希望,关于选择circRNA-miRNA对进行功能分析的标准以及提供验证circRNA-miRNA相互作用的标准方法的批判性讨论,将促进我们对circRNAs作为新型基因调节因子的理解。本文分类为:调控RNAs/RNAi/核糖开关>调控RNA翻译>调控RNA方法>细胞中的RNA分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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