Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy.

IF 1.3 4区医学 Q3 PATHOLOGY Pediatric and Developmental Pathology Pub Date : 2024-03-01 Epub Date: 2023-09-25 DOI:10.1177/10935266231195166

Charlotte F Kim, Chrystalle Katte Carreon, Kaitlyn E James, Sara V Bates, Sarah B Mueller, Theonia K Boyd, Drucilla J Roberts

{"title":"Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy.","authors":"Charlotte F Kim, Chrystalle Katte Carreon, Kaitlyn E James, Sara V Bates, Sarah B Mueller, Theonia K Boyd, Drucilla J Roberts","doi":"10.1177/10935266231195166","DOIUrl":null,"url":null,"abstract":"Objective: To elucidate particular placental pathology findings that are associated with hypoxic ischemic encephalopathy (HIE) and determine which patterns are associated with adverse fetal/neonatal outcomes.Study design: Multi-institutional retrospective case-control study of newborns with HIE (2002-2022) and controls. Four perinatal pathologists performed gross and histologic evaluation of placentas of cases and controls.Results: A total of 265 placentas of neonates with HIE and 122 controls were examined. Infants with HIE were more likely to have anatomic umbilical cord abnormalities (19.7% vs 7.4%, P = .003), fetal inflammatory response in the setting of amniotic fluid infection (27.7% vs 13.9%, P = .004), and fetal vascular malperfusion (30.6% vs 9.0%, P = <.001) versus controls. Fetal vascular malperfusion with maternal vascular malperfusion was more common in those who died of disease (P = .01).Conclusion: Placental pathology examination of neonates with HIE may improve our understanding of this disorder and its adverse outcomes.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric and Developmental Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10935266231195166","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To elucidate particular placental pathology findings that are associated with hypoxic ischemic encephalopathy (HIE) and determine which patterns are associated with adverse fetal/neonatal outcomes.

Study design: Multi-institutional retrospective case-control study of newborns with HIE (2002-2022) and controls. Four perinatal pathologists performed gross and histologic evaluation of placentas of cases and controls.

Results: A total of 265 placentas of neonates with HIE and 122 controls were examined. Infants with HIE were more likely to have anatomic umbilical cord abnormalities (19.7% vs 7.4%, P = .003), fetal inflammatory response in the setting of amniotic fluid infection (27.7% vs 13.9%, P = .004), and fetal vascular malperfusion (30.6% vs 9.0%, P = <.001) versus controls. Fetal vascular malperfusion with maternal vascular malperfusion was more common in those who died of disease (P = .01).

Conclusion: Placental pathology examination of neonates with HIE may improve our understanding of this disorder and its adverse outcomes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

新生儿缺氧缺血性脑病相关的大体和组织学胎盘异常。

目的：阐明与缺氧缺血性脑病（HIE）相关的胎盘病理学表现，并确定哪些模式与胎儿/新生儿的不良结局相关。研究设计：新生儿缺氧缺血性脑病（2002-2022）和对照组的多机构回顾性病例对照研究。四名围产期病理学家对病例和对照组的胎盘进行了大体和组织学评估。结果：对265例HIE新生儿胎盘及122例正常新生儿进行了检查。患有HIE的婴儿更有可能出现脐带解剖异常（19.7%对7.4%，P = .003），羊水感染时的胎儿炎症反应（27.7%vs13.9%，P = .004）和胎儿血管灌注异常（30.6%对9.0%，P = P = .结论：新生儿缺氧缺血性脑病的胎盘病理检查可以提高我们对该疾病及其不良后果的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.