Interactions of mesenchymal stromal/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2023-09-22 DOI:10.1016/j.cellimm.2023.104771
Sajad Dehnavi , Mahvash Sadeghi , Jalil Tavakol Afshari , Mojgan Mohammadi
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引用次数: 1

Abstract

Rheumatoid arthritis (RA) is considered to be a degenerative and progressive autoimmune disorder. Although several medicinal regimens are used to treat RA, potential adverse events such as metabolic disorders and increased risk of infection, as well as drug resistance in some patients, make it essential to find an effective and safe therapeutic approach. Mesenchymal stromal/stem cells (MSCs) are a group of non-hematopoietic stromal cells with immunomodulatory and inhibitory potential. These cells exert their regulatory properties through direct cell-to-cell interactions and paracrine effects on various immune and non-immune cells. As conventional therapeutic approaches for RA are limited due to their side effects, and some patients became refractory to the treatment, MSCs are considered as a promising alternative treatment for RA. In this review, we introduced various experimental and clinical studies conducted to evaluate the therapeutic effects of MSCs on animal models of arthritis and RA patients. Then, possible modulatory and suppressive effects of MSCs on different innate and adaptive immune cells, including dendritic cells, neutrophils, macrophages, natural killer cells, B lymphocytes, and various subtypes of T cells, were categorized and summarized. Finally, limitations and future considerations for the efficient application of MSCs as a therapeutic approach in RA patients were presented.

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基于MSC的类风湿性关节炎治疗方法后间充质基质/干细胞和免疫细胞的相互作用。
类风湿性关节炎(RA)被认为是一种退行性和进行性自身免疫性疾病。尽管有几种药物方案用于治疗RA,但潜在的不良事件,如代谢紊乱和感染风险增加,以及一些患者的耐药性,使得找到有效和安全的治疗方法至关重要。间充质基质/干细胞是一组具有免疫调节和抑制潜力的非造血基质细胞。这些细胞通过直接的细胞间相互作用和对各种免疫细胞和非免疫细胞的旁分泌作用发挥其调节特性。由于RA的传统治疗方法因其副作用而受到限制,并且一些患者对治疗变得难治,MSCs被认为是RA的一种有前途的替代治疗方法。在这篇综述中,我们介绍了各种实验和临床研究,以评估骨髓间充质干细胞对关节炎和RA患者动物模型的治疗效果。然后,对MSCs对不同先天和适应性免疫细胞的可能调节和抑制作用进行了分类和总结,包括树突状细胞、中性粒细胞、巨噬细胞、自然杀伤细胞、B淋巴细胞和各种亚型的T细胞。最后,介绍了骨髓间充质干细胞作为RA患者有效治疗方法的局限性和未来的考虑因素。
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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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