Sociodemographic and clinical factors associated with prescription of first- versus second-generation long-acting antipsychotics in incarcerated adult males.

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY International Clinical Psychopharmacology Pub Date : 2024-07-01 Epub Date: 2023-10-02 DOI:10.1097/YIC.0000000000000516
Enrico Capuzzi, Carla Laura Di Forti, Alice Caldiroli, Francesca Cova, Teresa Surace, Massimiliano Buoli, Massimo Clerici
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Abstract

Information on patterns of prescription of long-acting injection (LAI) antipsychotics among people who are incarcerated is lacking. Therefore, we aimed to evaluate prescribing rates for first-generation antipsychotic (FGA)-LAI versus second-generation antipsychotic (SGA)-LAI and to identify the factors associated with the prescription of one of the two classes of LAI. A cross-sectional study was conducted among incarcerated adult males hosted in Monza detention center between January 2013 and April 2023. Socio-demographic and clinical data were retrospectively collected. Descriptive and univariate statistics as well as logistic regression analyses were performed. Data were available for 135 consecutive incarcerated adult males with different mental disorders who received a LAI as part of their treatment. 75.6% of our sample was treated with FGA-LAIs, with haloperidol as the most commonly prescribed drug, followed by zuclopentixol and aripiprazole. Diagnosis of bipolar disorder and concomitant administration of antidepressants were statistically significant predictors of SGA-LAI prescription. Some patients' characteristics may influence prescription patterns in prison. Further longitudinal studies with larger samples should confirm these findings.

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在被监禁的成年男性中,与第一代和第二代长效抗精神病药物处方相关的社会形态和临床因素。
缺乏关于被监禁者中长效注射(LAI)抗精神病药物处方模式的信息。因此,我们旨在评估第一代抗精神病药物(FGA)-LAI与第二代抗精神疾病药物(SGA)-LAI的处方率,并确定与两类LAI之一的处方相关的因素。2013年1月至2023年4月,在蒙扎拘留中心收容的被监禁成年男性中进行了一项横断面研究。回顾性收集社会人口学和临床数据。进行描述性和单变量统计以及逻辑回归分析。有135名患有不同精神障碍的连续监禁成年男性的数据,他们接受了LAI作为治疗的一部分。75.6%的样本接受了FGA-LAIs治疗,氟哌啶醇是最常见的处方药,其次是左氯戊醇和阿立哌唑。双相情感障碍的诊断和同时服用抗抑郁药是SGA-LAI处方的统计学显著预测因素。一些患者的特征可能会影响监狱中的处方模式。对更大样本的进一步纵向研究应该证实这些发现。
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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