[Research advances on the mechanism of oral mucosal stem cells in promoting wound healing].

Q3 Medicine Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Pub Date : 2023-05-20 DOI:10.3760/cma.j.cn501225-20220730-00321

Z R Wei, Y Dong, G S Li, L B Liu

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Abstract

Wound healing is a complex process that requires the participation of multiple cells and cytokines. During the process of wound healing, abnormality in any stage of the process may lead to the development of a chronic refractory wound. Research has confirmed that various stem cells can promote wound healing, but some stem cells are limited in clinical application due to difficulties in isolation, susceptibility to apoptosis, ethical and legal issues. Oral mucosal stem cells (OMSCs) can avoid the above problems. This type of stem cells has the characteristics of embryonic stem cells, immune regulatory ability, and strong homogeneity. It plays an important role in the process of scarless oral wound healing, and has become a research hotspot in promoting wound healing and reducing scar formation. This article reviews the research on the mechanism, clinical application prospects, and current problems of OMSCs in promoting wound healing.

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【口腔黏膜干细胞促进伤口愈合机制研究进展】。

伤口愈合是一个复杂的过程，需要多种细胞和细胞因子的参与。在伤口愈合过程中，任何阶段的异常都可能导致慢性难治性伤口的发展。研究证实，各种干细胞可以促进伤口愈合，但由于分离困难、易发生细胞凋亡、伦理和法律问题，一些干细胞在临床应用中受到限制。口腔粘膜干细胞（OMSCs）可以避免上述问题。这类干细胞具有胚胎干细胞的特点，具有免疫调节能力，具有较强的同质性。它在口腔无瘢痕伤口愈合过程中发挥着重要作用，已成为促进伤口愈合和减少瘢痕形成的研究热点。本文综述了OMSCs促进伤口愈合的机制、临床应用前景以及目前存在的问题。

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来源期刊

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Medicine-Medicine (all)

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8511

期刊介绍： The Chinese Journal of Burns is the most authoritative one in academic circles of burn medicine in China. It adheres to the principle of combining theory with practice and integrating popularization with progress and reflects advancements in clinical and scientific research in the field of burn in China. The readers of the journal include burn and plastic clinicians, and researchers focusing on burn area. The burn refers to many correlative medicine including pathophysiology, pathology, immunology, microbiology, biochemistry, cell biology, molecular biology, and bioengineering, etc. Shock, infection, internal organ injury, electrolytes and acid-base, wound repair and reconstruction, rehabilitation, all of which are also the basic problems of surgery.