Pediatric Multiple Sclerosis: Changing the Trajectory of Progression.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2023-11-01 Epub Date: 2023-10-04 DOI:10.1007/s11910-023-01300-3

Daniela Castillo Villagrán, E Ann Yeh

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Abstract

Purpose of review: Multiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change developmental trajectories associated with the disease. In this paper, we will review diagnostic criteria for pediatric multiple sclerosis, outcomes, differential diagnosis, and current therapeutic approaches.

Recent findings: Recent studies have demonstrated the utility of newer structural and functional metrics in facilitating early recognition and diagnosis of pediatric MS. Knowledge about disease-modifying therapies in pediatric multiple sclerosis has expanded in recent years: important developmental impacts of earlier therapeutic intervention and use of highly effective therapies have been demonstrated. Pediatric MS is characterized by highly active disease and high disease burden. Advances in knowledge have led to early identification, diagnosis, and treatment. Lifestyle-related interventions and higher efficacy therapies are currently undergoing investigation.

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小儿多发性硬化症：改变进展轨迹。

综述目的：多发性硬化症是一种中枢神经系统的慢性炎症性疾病。当在儿童和青少年身上观察时，大脑发育和成熟的关键阶段可能会受到影响。在这一人群中及时识别多发性硬化症是至关重要的，因为早期干预疾病改良疗法可能会改变与疾病相关的发展轨迹。在这篇论文中，我们将回顾儿科多发性硬化症的诊断标准、结果、鉴别诊断和当前的治疗方法。最近的发现：最近的研究证明了新的结构和功能指标在促进儿科多发性硬化症的早期识别和诊断方面的效用。近年来，关于儿童多发性硬化症疾病改良疗法的知识有所扩展：早期治疗干预和使用高效疗法对发育的重要影响已经得到证实。儿科多发性硬化症的特点是疾病活动性强，疾病负担高。知识的进步导致了早期识别、诊断和治疗。与生活方式相关的干预措施和更高效的疗法目前正在进行调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.