Aging adipose tissue, insulin resistance, and type 2 diabetes.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-19 DOI:10.1007/s10522-023-10067-6
Yixuan Zhao, Rensong Yue
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Abstract

With the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising. Aging affects the tissues and organs of the whole body, which is the result of various physiological and pathological processes. Adipose tissue has a high degree of plasticity and changes with aging. Aging changes the distribution of adipose tissue, affects adipogenesis, browning characteristics, inflammatory status and adipokine secretion, and increases lipotoxicity. These age-dependent changes in adipose tissue are an important cause of insulin resistance and T2D. Understanding adipose tissue changes can help promote healthy aging process. This review summarizes changes in adipose tissue ascribable to aging, with a focus on the role of aging adipose tissue in insulin resistance and T2D.

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衰老的脂肪组织、胰岛素抵抗和2型糖尿病。
随着人口老龄化的加剧,2型糖尿病(T2D)的患病率也在上升。衰老影响全身的组织和器官,是各种生理和病理过程的结果。脂肪组织具有高度的可塑性,并随着年龄的增长而变化。衰老改变脂肪组织的分布,影响脂肪生成、褐变特征、炎症状态和脂肪因子分泌,并增加脂肪毒性。脂肪组织中这些与年龄相关的变化是胰岛素抵抗和T2D的重要原因。了解脂肪组织的变化有助于促进健康的衰老过程。这篇综述总结了可归因于衰老的脂肪组织变化,重点是衰老脂肪组织在胰岛素抵抗和T2D中的作用。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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