Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms.

IF 10.1 2区 生物学 Q1 MICROBIOLOGY FEMS microbiology reviews Pub Date : 2023-09-05 DOI:10.1093/femsre/fuad054
Moumita Ghosh, Shikha Raghav, Puja Ghosh, Swagatam Maity, Kavery Mohela, Deepti Jain
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引用次数: 1

Abstract

Pseudomonas aeruginosa is an opportunistic human pathogen responsible for acute and chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop into biofilms, which are sessile bacterial communities adhered to substratum and encapsulated in layers of self-produced exopolysaccharides. These biofilms provide enhanced protection from the host immune system and resilience towards antibiotics, which poses a challenge for treatment. Various strategies have been expended for combating biofilms, which involve inhibiting biofilm formation or promoting their dispersal. The current remediation approaches offer some hope for clinical usage, however, treatment and eradication of preformed biofilms is still a challenge. Thus, identifying novel targets and understanding the detailed mechanism of biofilm regulation becomes imperative. Structure-based drug discovery (SBDD) provides a powerful tool that exploits the knowledge of atomic resolution details of the targets to search for high affinity ligands. This review describes the available structural information on the putative target protein structures that can be utilized for high throughput in silico drug discovery against P. aeruginosa biofilms. Integrating available structural information on the target proteins in readily accessible format will accelerate the process of drug discovery.

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缓解铜绿假单胞菌生物膜的新药物靶点的结构分析。
铜绿假单胞菌是一种机会性人类病原体,可导致急性和慢性难以治疗的感染。铜绿假单胞菌的持久性是由于它能够发育成生物膜,生物膜是附着在基质上并包裹在自产胞外多糖层中的固着细菌群落。这些生物膜增强了对宿主免疫系统的保护,并增强了对抗生素的抵抗力,这对治疗提出了挑战。已经花费了各种策略来对抗生物膜,包括抑制生物膜的形成或促进其扩散。目前的修复方法为临床应用提供了一些希望,但治疗和根除预先形成的生物膜仍然是一个挑战。因此,识别新的靶标并了解生物膜调控的详细机制变得势在必行。基于结构的药物发现(SBDD)提供了一种强大的工具,利用靶点原子分辨率细节的知识来寻找高亲和力配体。这篇综述描述了可用于针对铜绿假单胞菌生物膜的高通量计算机药物发现的假定靶蛋白结构的可用结构信息。以易于获取的形式整合靶蛋白的可用结构信息将加速药物发现的进程。
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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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