Circulating cell-free DNA and its association with cardiovascular disease: what we know and future perspectives.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-10-06 DOI:10.1097/MOL.0000000000000907

Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen

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Abstract

Purpose of review: The aim of this review is to explore a possible link between cell-free DNA (cfDNA) and cardiovascular disease (CVD), which may hold valuable potential for future diagnostics.

Recent findings: cfDNA has become topic of high interest across several medical fields. cfDNA is used as a diagnostic biomarker in cancer, prenatal care, and transplantation. In addition, cfDNA may play an unrecognized role in biological processes that are involved in or underlying various disease states, for example, inflammation. Elevated levels of cfDNA are associated with various elements of CVD, cardio-metabolic risk factors, and autoimmune diseases. Mitochondrial cfDNA and neutrophil extracellular traps may play distinct roles. Total circulating cfDNA may reflect the unspecific accumulation of stressors and the organism's susceptibility and resilience to such stressors. As such, cfDNA, in a stressful situation, may provide predictive value for future development of CVD. We suggest exploring such possibility through a large-scale prospective cohort study of pregnant women.

Summary: There is no doubt that cfDNA is a valuable biomarker. For CVD, its potential is indicated but less explored. New studies may identify cfDNA as a valuable circulating cardiovascular risk marker to help improve risk stratification.

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循环无细胞DNA及其与心血管疾病的关系：我们所知道的和未来的展望。

综述目的：本综述的目的是探索无细胞DNA（cfDNA）与心血管疾病（CVD）之间的可能联系，这可能对未来的诊断具有宝贵的潜力。最近的发现：cfDNA已经成为多个医学领域高度关注的话题。cfDNA被用作癌症、产前护理和移植的诊断生物标志物。此外，cfDNA可能在参与或潜在的各种疾病状态（例如炎症）的生物过程中发挥未被认识的作用。cfDNA水平升高与心血管疾病、心脏代谢危险因素和自身免疫性疾病的各种因素有关。线粒体cfDNA和中性粒细胞外陷阱可能发挥不同的作用。总循环cfDNA可能反映应激源的非特异性积累以及生物体对这些应激源的易感性和恢复力。因此，在紧张的情况下，cfDNA可能为CVD的未来发展提供预测价值。我们建议通过对孕妇进行大规模前瞻性队列研究来探索这种可能性。摘要：毫无疑问，cfDNA是一种有价值的生物标志物。对于CVD，其潜力已被指出，但探索较少。新的研究可能会确定cfDNA是一种有价值的循环心血管风险标志物，有助于改善风险分层。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.