Quantification of dynamic cerebral autoregulation: welcome to the jungle!

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY Clinical Autonomic Research Pub Date : 2023-12-01 Epub Date: 2023-09-27 DOI:10.1007/s10286-023-00986-2

Patrice Brassard, Marc-Antoine Roy, Joel S Burma, Lawrence Labrecque, Jonathan D Smirl

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Abstract

Purpose: Patients with dysautonomia often experience symptoms such as dizziness, syncope, blurred vision and brain fog. Dynamic cerebral autoregulation, or the ability of the cerebrovasculature to react to transient changes in arterial blood pressure, could be associated with these symptoms.

Methods: In this narrative review, we go beyond the classical view of cerebral autoregulation to discuss dynamic cerebral autoregulation, focusing on recent advances pitfalls and future directions.

Results: Following some historical background, this narrative review provides a brief overview of the concept of cerebral autoregulation, with a focus on the quantification of dynamic cerebral autoregulation. We then discuss the main protocols and analytical approaches to assess dynamic cerebral autoregulation, including recent advances and important issues which need to be tackled.

Conclusion: The researcher or clinician new to this field needs an adequate comprehension of the toolbox they have to adequately assess, and interpret, the complex relationship between arterial blood pressure and cerebral blood flow in healthy individuals and clinical populations, including patients with autonomic disorders.

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动态大脑自动调节的量化：欢迎来到丛林！

目的：自主神经功能障碍患者经常出现头晕、晕厥、视力模糊和脑雾等症状。动态大脑自动调节，或脑血管系统对动脉血压的短暂变化做出反应的能力，可能与这些症状有关。方法：在这篇叙述性综述中，我们超越了大脑自动调节的经典观点，讨论了动态大脑自动调节，重点讨论了最近的进展、陷阱和未来的方向。结果：在一定的历史背景下，这篇叙述性综述对大脑自动调节的概念进行了简要概述，重点是动态脑自动调节的量化。然后，我们讨论了评估动态大脑自动调节的主要方案和分析方法，包括最新进展和需要解决的重要问题。结论：新进入该领域的研究人员或临床医生需要充分理解他们所拥有的工具箱，以充分评估和解释健康个体和临床人群（包括自主神经障碍患者）的动脉血压和脑血流量之间的复杂关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Autonomic Research 医学-临床神经学

CiteScore

7.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Autonomic Research aims to draw together and disseminate research work from various disciplines and specialties dealing with clinical problems resulting from autonomic dysfunction. Areas to be covered include: cardiovascular system, neurology, diabetes, endocrinology, urology, pain disorders, ophthalmology, gastroenterology, toxicology and clinical pharmacology, skin infectious diseases, renal disease. This journal is an essential source of new information for everyone working in areas involving the autonomic nervous system. A major feature of Clinical Autonomic Research is its speed of publication coupled with the highest refereeing standards.