Analysis of multiple organ function damage in patients with severe COVID-19 pneumonia.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI:10.5937/jomb0-41502

Shiyan Feng, Fengxin Wang, Weibo Wu, Yinfeng Li, Chuming Chen, Jianming Li, Mengli Cao, Ling Peng, Peiyan Zhang, Fuxiang Wang

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Abstract

Background: This study aims to analyze the changes and significance of organ function indices in patients with severe Coronavirus Disease 2019 (COVID-19) pneumonia for prediction of major organ damages and guiding treatment schemes.

Methods: 63 patients with severe COVID-19 pneumonia were selected as the severe group and 73 patients with mild syndromes were selected as the mild group. SAS9.4 software was used for statistical analysis of the data.

Results: Levels of ALT, AST, cTnI, Cr, PT, APTT and Ddimer of the severe group were significantly higher while PLT was lower than those of the mild group. The data of all quantitative variables were converted into categorical variables. Significantly higher levels of AST, ALB, D-dimer and higher proportion of bilateral lung involvement were observed from the severe group comparing to those in the mild group, while the difference in the other indices between the two groups was insignificant in statistical perspective.

Conclusions: There are significant differences in the levels of multiple organ function indices between the severe group and the mild group of patients with COVID-19 pneumonia infection. Through examining the relevant indices, conditions of patients' multiple organ function damage could be predicted and used as guidance of treatment.

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新冠肺炎重症患者多器官功能损害分析。

背景：本研究旨在分析2019年新冠肺炎重症肺炎患者器官功能指标的变化及其意义，以预测主要器官损伤并指导治疗方案。方法：选择63例新冠肺炎重症患者为重症组，73例轻症患者为轻症组。采用SAS9.4软件对数据进行统计分析。结果：重症组ALT、AST、cTnI、Cr、PT、APTT和D二聚体水平明显高于轻症组，PLT低于轻症组。将所有定量变量的数据转换为分类变量。与轻度组相比，重度组的AST、ALB、D-二聚体水平显著升高，双侧肺受累比例也更高，而从统计学角度来看，两组之间其他指标的差异并不显著。结论：新冠肺炎感染者重症组与轻症组多脏器功能指标水平存在显著差异。通过检测相关指标，可以预测患者多器官功能损害的情况，并作为治疗的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.