Citicoline on the Barthel Index: Severe and moderate brain injury.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.4103/ijp.ijp_570_21

Mehdi Mahmoodkhani, Bahram Aminmansour, Mehdi Shafiei, Mohammadreza Hasas, Donya Sheibani Tehrani

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Abstract

Introduction: Traumatic brain injury (TBI) is a paramount factor in mortality and morbidity. The clinical trials conducted to investigate the efficacy of neuroprotective agents, such as citicoline, as a therapeutic alternative for TBI have presented divergent findings. Therefore, this study aimed to evaluate and compare citicoline's effect on the Barthel Index in patients with severe and moderate brain injury.

Materials and methods: The study is a randomized clinical trial. Patients in the case group (35 patients) were treated with citicoline and the control group (34 patients) received a placebo. Data were analyzed using SPSS 16 software.

Results: The results showed that changes in the Glasgow Coma Scale, changes in quadriceps muscle force score, Barthel Index score changes, achieving the status without intubation, and spontaneous breathing in patients treated with citicoline were not a statistically significant difference in the two groups (P > 0.05).

Conclusion: Findings revealed that citicoline did not impact the recovery process of severe and moderate TBI patients.

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Citicoline对Barthel指数的影响：严重和中度脑损伤。

引言：创伤性脑损伤（TBI）是死亡率和发病率的重要因素。为研究胞磷胆碱等神经保护剂作为TBI治疗替代品的疗效而进行的临床试验呈现出不同的结果。因此，本研究旨在评估和比较胞磷胆碱对严重和中度脑损伤患者Barthel指数的影响。材料与方法：本研究为随机临床试验。病例组（35例）接受胞磷胆碱治疗，对照组（34例）接受安慰剂治疗。数据分析采用SPSS 16软件。结果：格拉斯哥昏迷量表变化、股四头肌肌力评分变化、Barthel指数评分变化，达到无插管状态，结论：胞磷胆碱对重、中度TBI患者的恢复过程无明显影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.