Prevalence and assessment of frailty in interstitial lung disease - a systematic review and meta-analysis.

IF 3.5 3区医学 Q2 RESPIRATORY SYSTEM Chronic Respiratory Disease Pub Date : 2023-01-01 DOI:10.1177/14799731231196582

Angela Weber, Ilena Müller, Annina E Büchi, Sabina A Guler

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Abstract

Background: Frailty is a multisystem dysregulation that challenges homeostasis and increases vulnerability towards stressors. In patients with interstitial lung diseases (ILD) frailty is associated with poorer lung function, greater physical impairment, and higher symptom burden. Our understanding of the prevalence of frailty in ILD and consequently its impact on the ILD population is limited.

Objective and methods: We aimed to systematically review frailty assessment tools and to determine frailty prevalence across different ILD cohorts. Meta-analyses were used to calculate the pooled prevalence of frailty in the ILD population.

Results: We identified 26 studies (15 full-texts, 11 conference abstracts) including a total of 4614 patients with ILD. The most commonly used frailty assessment tools were the Fried Frailty Phenotype (FFP), the Short Physical Performance Battery (SPPB), and the cumulative Frailty Index (FI). Data allowed for meta-analyses of FFP and SPPB prevalence. The pooled prevalence of frailty was 35% (95% CI 25%-45%) by FFP, and 19% (95% CI 12%-28%) by SPPB.

Conclusions: Frailty is common in ILD, with considerable variability of frailty prevalence depending on the frailty assessment tool used. These findings highlight the importance of frailty in ILD and the need for a standardized approach to frailty assessment in this population.

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间质性肺病虚弱的患病率和评估——一项系统综述和荟萃分析。

背景：虚弱是一种多系统失调，挑战体内平衡，增加对压力源的脆弱性。在间质性肺病（ILD）患者中，虚弱与肺功能较差、身体损伤更大和症状负担更高有关。我们对ILD中虚弱的患病率及其对ILD人群的影响的了解是有限的。目的和方法：我们旨在系统地回顾虚弱评估工具，并确定不同ILD队列的虚弱患病率。荟萃分析用于计算ILD人群中虚弱的合并患病率。结果：我们确定了26项研究（15篇全文，11篇会议摘要），包括4614名ILD患者。最常用的虚弱评估工具是油炸虚弱表型（FFP）、短期物理性能电池（SPPB）和累积虚弱指数（FI）。允许对FFP和SPPB患病率进行荟萃分析的数据。FFP和SPPB的虚弱综合患病率分别为35%（95%CI 25%-45%）和19%（95%CI 12%-28%）。结论：虚弱在ILD中很常见，根据使用的虚弱评估工具，虚弱患病率有很大的可变性。这些发现强调了虚弱在ILD中的重要性，以及对该人群进行虚弱评估的标准化方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Respiratory Disease RESPIRATORY SYSTEM-

CiteScore

5.90

自引率

7.30%

发文量

审稿时长

11 weeks

期刊介绍： Chronic Respiratory Disease is a peer-reviewed, open access, scholarly journal, created in response to the rising incidence of chronic respiratory diseases worldwide. It publishes high quality research papers and original articles that have immediate relevance to clinical practice and its multi-disciplinary perspective reflects the nature of modern treatment. The journal provides a high quality, multi-disciplinary focus for the publication of original papers, reviews and commentary in the broad area of chronic respiratory disease, particularly its treatment and management.