Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) in Canada: treatment update and the role of new IV antimicrobials.

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2023-10-09 DOI:10.1080/14787210.2023.2268287
Coleman Rotstein, Joseph P Lynch, George G Zhanel
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Abstract

Introduction: Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) continue to be common infections causing significant morbidity and mortality worldwide. The timely initiation of empiric antimicrobial therapy is essential. In this paper, we provide a focused expert opinion on the current and potential empiric antimicrobial treatment options in HABP and VABP in Canada influenced by antimicrobial resistance impacting the use of older agents as well as available new intravenous (IV) antimicrobials.

Areas covered: The authors discuss treatment options for HABP and VABP in Canada. In addition, we focus on the potential role of new IV antimicrobials recently introduced to Canada. A literature search of HABP and VABP treatments was performed via PubMed (up to March 2023), using the following key words: monotherapy, combination therapy, aminoglycosides, carbapenems, cephalosporins, fluoroquinolones, penicillins as well as amoxicillin/clavulanate, ceftobiprole, ceftolozane/tazobactam, dalbavancin, and fosfomycin.

Expert opinion: Empiric antimicrobial treatment for HABP and VABP in Canada continues to focus on both the severity of illness and the presence/absence of patient risk factors for antimicrobial resistance. The role of new IV antimicrobials in the empiric treatment for HABP and VABP depends on their antimicrobial activity and published data on efficacy and safety and influenced by Health Canada-approved indications.

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加拿大的医院获得性细菌性肺炎(HABP)和呼吸机相关细菌性肺炎:治疗更新和新型静脉抗菌药物的作用。
引言:医院获得性细菌性肺炎(HABP)和呼吸机相关细菌性肺炎仍然是常见的感染,在全球范围内造成显著的发病率和死亡率。及时开始经验性抗菌治疗至关重要。在这篇论文中,我们就加拿大HABP和VABP目前和潜在的经验性抗菌治疗方案提供了一个集中的专家意见,这些方案受到抗菌耐药性的影响,影响了旧药物的使用,以及可用的新型静脉(IV)抗菌剂。涵盖领域:作者讨论了加拿大HABP和VABP的治疗方案。此外,我们还关注最近引入加拿大的新型静脉注射抗菌药物的潜在作用。通过PubMed(截至2023年3月)检索了HABP和VABP治疗的文献,关键词为:单药治疗、联合治疗、氨基糖苷类、碳青霉烯类、头孢菌素类、氟喹诺酮类、青霉素类以及阿莫西林/克拉维酸、头孢托比唑、头孢托洛唑/他唑巴坦、达尔巴万星和磷霉素。专家意见:加拿大HABP和VABP的经验性抗菌治疗继续关注疾病的严重程度和患者是否存在抗微生物耐药性的风险因素。新型静脉注射抗菌药物在HABP和VABP经验性治疗中的作用取决于其抗菌活性、已发表的疗效和安全性数据以及加拿大卫生部批准的适应症的影响。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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