Evaluation of serum vitamin B12 levels in patients with COVID-19 infection: A case-control study.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI:10.5937/jomb0-42357

Yılmaz Sezgin

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引用次数: 1

Abstract

Background: COVID-19 disease affects the respiratory and cardiovascular systems. Vitamin B12 has been associated with A1AT, one of the protective factors of lung tissue, and homocysteine among the cardiovascular risk factors. Therefore we suggest that low vitamin B12 levels are associated with a disposition to COVID-19 infection. This study aims to determine whether there is a relationship between COVID-19 infection and serum vitamin B12 levels.

Methods: This research is a case-control study. Seventy-six people with COVID-19 constituted the case group. Seventy-six people without COVID-19 formed the control group. Vitamin B12 and homocysteine levels of 152 patients included in the study were analyzed.

Results: The odds ratio for vitamin B12 was 0.99 (0.978-0.995). When the value of the vitamin B12 variable decreases by one unit, the risk of COVID-19 increases by 1%. The odds ratio for homocysteine was 1.81 (1.414-2.325). When the value of the homocysteine variable increases by one unit, the risk of COVID-19 increases by 1.81 times. According to ROC analysis, when serum vitamin B12 is below 222.5 ng/L and homocysteine is above 13.7 mmol/L, it may increase the risk of COVID-19.

Conclusions: We suggest that patients with low vitamin B12 levels and high homocysteine levels are more severely affected by COVID-19 infection.

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新冠肺炎感染患者血清维生素B12水平的评估：一项病例对照研究。

背景：新冠肺炎疾病影响呼吸系统和心血管系统。维生素B12与肺组织的保护因子之一A1AT和心血管危险因素中的同型半胱氨酸有关。因此，我们认为维生素B12水平低与新冠肺炎感染倾向有关。本研究旨在确定新冠肺炎感染与血清维生素B12水平之间是否存在关系。方法：本研究为病例对照研究。76名新冠肺炎患者构成病例组。76名无新冠肺炎的患者组成对照组。对纳入研究的152名患者的维生素B12和同型半胱氨酸水平进行了分析。结果：维生素B12的比值比为0.99（0.978-0.995）。当维生素B12变量的值降低一个单位时，患新冠肺炎的风险增加1%。同型半胱氨酸的比值比为1.81（1.414-2.325）。当同型半胱氨酸变量的值增加一个单位时，新冠肺炎的风险增加1.81倍。根据ROC分析，当血清维生素B12低于222.5纳克/升，同型半胱氨酸高于13.7毫摩尔/升时，可能会增加患新冠肺炎的风险。结论：我们认为，维生素B12水平低、同型半胱氨酸水平高的患者受新冠肺炎感染的影响更严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.