Could Aneurysm and Atherosclerosis-Associated MicroRNAs (miR 24-1-5p, miR 34a-5p, miR 126-5p, miR 143-5p, miR 145-5p) Also Be Associated with Coronary Artery Ectasia?

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Genetic testing and molecular biomarkers Pub Date : 2023-09-01 DOI:10.1089/gtmb.2023.0002
Zafer Yalım, Serap Tutgun Onrat, Ibrahim Etem Dural, Ersel Onrat
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Abstract

Background: Coronary artery ectasia (CAE), known for localized or diffuse excessive dilatation of the coronary artery, has an unknown etiology, but it has been reported that the underlying cause may be atherosclerosis and genetic changes that may affect the arterial lumen. MicroRNAs have been shown to have an effect in aneurysm diseases and are known to contribute to vascular development and atherosclerosis. The purpose of this study was to investigate whether they are also associated with CAE. Methods: This cross-sectional study consisted of 25 patients with CAE and 25 subjects with normal coronary arteries. Blood was collected and miRNA expression was detected using the Rotor-GeneQ real-time polymerase chain reaction cycler (Qiagen) to investigate expression levels of miR-24-1-5p, miR-34a-5p, miR-126-5p, miR-143-5p, and miR-145-5p. Results: Demographic variables of CAE (mean age 59.5 ± 1.7; 12 women) and controls (mean age 57.2 ± 2.1; 16 women) were similar. miR-126-5p (p = 0.014) and miR-145-5p (p = 0.003) levels were found to be <2-fold upregulated in CAE compared to controls; miR-143-5p also showed upregulation, but it was not significant (p = 0.078). Conversely, miR-24-1-5p (p = 0.032) levels were downregulated in CAE compared to controls. miR-34a-5p was also downregulated, but this was not considered significant (p = 0.185). Conclusions: According to our study findings, miR-126-5p, miR-145-5p, and miR-24-1-5p may be associated with CAE. These microRNAs could be of diagnostic and therapeutic significance for further studies of CAE involving abnormal angiogenesis and vascular disorders and potentially serve as useful biomarkers.

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动脉瘤和动脉粥样硬化相关的微小RNA(miR24-1-5p、miR34a-5p、miR126-5p、miR143-5p和miR145-5p)是否也与冠状动脉扩张有关?
背景:冠状动脉扩张症(CAE)以局部或弥漫性冠状动脉过度扩张而闻名,其病因尚不清楚,但据报道,其潜在原因可能是动脉粥样硬化和可能影响动脉腔的遗传变化。微小RNA已被证明对动脉瘤疾病有影响,并已知有助于血管发育和动脉粥样硬化。本研究的目的是调查它们是否也与CAE有关。方法:这项横断面研究包括25例CAE患者和25例冠状动脉正常的受试者。采集血液并使用Rotor GeneQ实时聚合酶链式反应循环仪(Qiagen)检测miRNA表达,以研究miR-24-1-5p、miR-34a-5p、iR-126-5p、miR-143-5p和miR-145-5p的表达水平。结果:CAE的人口学变量(平均年龄59.5岁) ± 1.7;12名女性)和对照组(平均年龄57.2岁 ± 2.1;16名女性)相似。miR-126-5p(p = 0.014)和miR-145-5p(p = 0.003)水平的miR-143-5p也显示上调,但并不显著(p = 0.078)。相反,miR-24-1-5p(p = 0.032)水平与对照组相比被下调。miR-34a-5p也被下调,但这并不显著(p = 结论:根据我们的研究结果,miR-126-5p、miR-145-5p和miR-24-1-5p可能与CAE相关。这些微小RNA可能对涉及异常血管生成和血管疾病的CAE的进一步研究具有诊断和治疗意义,并可能作为有用的生物标志物。
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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
63
审稿时长
1 months
期刊介绍: Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling
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