Fereshteh Dorsareh, Gita Vahid-Dastjerdi, Abdelhakim Bouyahya, Mohammad Mehdi Zarshenas, Mostafa Rezaie, Woong Mo Yang, Ehsan Amiri-Ardekani
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引用次数: 1
Abstract
Background: Recurrent aphthous stomatitis (RAS) is the most common ulcerative disease that affects oral mucosa. The coating agents, topical analgesics, and topical steroids are usually used as treatment methods. Glycyrrhiza glabra has been used for RAS treatment based on its anti-inflammatory, antioxidant, and immunomodulatory properties. In this study, a systemic review on the therapeutic effect of topical licorice on RAS management was performed.
Methods: Science Direct, Scopus, Cochrane databases, PubMed Google Scholar, and ResearchGate were searched up to September 2021 to find all English randomized clinical trials studying the effect of G. glabra, or its compositions on RAS. Meta-analysis was not conducted because of data heterogeneity. Articles were reviewed qualitatively, and only those with a Jadad score ≥3 were included. Animal studies, in vitro, review papers, non-English papers, and case reports were excluded.
Results: Six studies with 314 subjects were included after screening. The result showed licorice has significant effects on RAS pain reduction, ulcer size, and healing time. Its effectiveness is related to its dose-dependent anti-inflammatory and antioxidant effects through several mechanisms. It also has antibacterial effects against Streptococci mutans and Porphyromonas gingivalis as another mechanism of action in RAS treatment. In addition, licorice can elevate the epidermal growth factor (EGF) level compared to the control group, which has an essential role in oral mucosal tissue integrity.
Conclusion: Licorice extract has been used in different dosage forms, including paste, patch, and mouthwash with concentrations of 1% or 5%. The healing time after licorice therapy is expected to be within 4-8 days. Licorice did not show any adverse effect in the intervention groups, indicating its effectiveness and safety in RAS treatment.
背景:复发性口腔炎(RAS)是影响口腔黏膜的最常见的溃疡性疾病。通常使用包衣剂、局部镇痛剂和局部类固醇作为治疗方法。光甘草因其抗炎、抗氧化和免疫调节特性而被用于RAS治疗。在本研究中,对局部甘草对RAS管理的治疗效果进行了系统综述。方法:检索截至2021年9月的Science Direct、Scopus、Cochrane数据库、PubMed Google Scholar和ResearchGate,以查找所有研究G.glabra或其组合物对RAS影响的英国随机临床试验。由于数据的异质性,没有进行荟萃分析。对文章进行了定性审查,仅包括Jadad评分≥3的文章。排除动物研究、体外研究、综述论文、非英文论文和病例报告。结果:筛选后纳入6项研究,314名受试者。结果表明,甘草对RAS疼痛减轻、溃疡大小和愈合时间有显著影响。其有效性通过多种机制与剂量依赖性抗炎和抗氧化作用有关。它还对变形链球菌和牙龈卟啉单胞菌具有抗菌作用,这是RAS治疗的另一种作用机制。此外,与对照组相比,甘草可以提高表皮生长因子(EGF)水平,这对口腔粘膜组织的完整性具有重要作用。结论:甘草提取物有不同的剂型,包括浓度为1%或5%的糊剂、贴片和漱口水。甘草治疗后的愈合时间预计在4-8天内。甘草在干预组中没有表现出任何不良反应,表明其在RAS治疗中的有效性和安全性。
期刊介绍:
The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of communication for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science research experiences on prevalent diseases in the region and analysis of various regional problems.