First implementation of dynamic oxygen-17 (¹⁷O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2024-02-01 Epub Date: 2023-09-22 DOI:10.1007/s10334-023-01119-6

Louise Ebersberger, Fabian J Kratzer, Vanessa L Franke, Armin M Nagel, Sebastian C Niesporek, Andreas Korzowski, Mark E Ladd, Heinz-Peter Schlemmer, Daniel Paech, Tanja Platt

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Abstract

Objective: First implementation of dynamic oxygen-17 (¹⁷O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.

Methods: Five healthy volunteers underwent a three-phase ¹⁷O gas (¹⁷O₂) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute ¹⁷O water (H₂¹⁷O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.

Results: The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of ¹⁷O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H₂¹⁷O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.

Discussion: The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic ¹⁷O MRI at 7 T.

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在人脑神经元刺激过程中，首次在7特斯拉下实现动态氧-17（17O）磁共振成像。

目的：首次在人脑神经元刺激过程中实现7特斯拉（T）的动态氧-17（17O）MRI。方法：对5名健康志愿者进行三相17O气体（17O2）吸入实验。采用右侧视觉刺激和右手手指敲击相结合的方法来实现对左大脑半球的神经元刺激。数据分析包括评估17O水（H217O）绝对浓度的相对部分体积（PV）校正的时间演变和没有PV校正的相对信号演变。使用单尾配对t检验进行统计分析。进行血氧水平依赖性（BOLD）实验以验证刺激模式。结果：与未受刺激的右侧相比，BOLD图显示受刺激的左侧视觉和感觉运动皮层有显著的活动。由于感兴趣的小区域（ROI），17O MR数据的PV校正导致高信号波动，噪声水平为10%，阻碍了进一步的定量分析。用PV校正对相对H217O信号的统计评估（p = 0.168）和不含（p = 0.382）在刺激的左侧和非刺激的右侧感觉运动ROI之间没有显示出显著差异。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.