K K Pierce, S S Whitehead, S A Diehl, G Naro, M C Carmolli, H He, C M Tibery, B P Sabundayo, B D Kirkpatrick, A P Durbin
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引用次数: 0
Abstract
All four serotypes of dengue virus (DENV) cause the full spectrum of disease. Therefore, vaccines must protect against all serotypes. To evaluate candidate vaccines, a human challenge model of dengue serotype 3 (rDEN30Δ30) was developed. All challenge virus recipients safely met the primary endpoint of viremia and secondary endpoints of rash and seroconversion to DENV-3.
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