Inflammasomes in human reproductive diseases.

IF 3.6 2区医学 Q2 DEVELOPMENTAL BIOLOGY Molecular human reproduction Pub Date : 2023-09-30 DOI:10.1093/molehr/gaad035

Yun Chen, Chenyun Miao, Ying Zhao, Liuqing Yang, Ruye Wang, Dan Shen, Ning Ren, Qin Zhang

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引用次数: 0

Abstract

Inflammasomes are multi-protein complexes localized within immune and non-immune cells that induce caspase activation, proinflammatory cytokine secretion, and ultimately pyroptosis-a type of cell death. Inflammasomes are involved in a variety of human diseases, especially acute or chronic inflammatory diseases. In this review, we focused on the strong correlation between the NLRP3 inflammasome and various reproductive diseases, including ovarian aging or premature ovarian insufficiency, PCOS, endometriosis, recurrent spontaneous abortion, preterm labor, pre-eclampsia, and male subfertility, as well as the multifaceted role of NLRP3 in the pathogenesis and treatment of these diseases. In addition, we provide an overview of the structure and amplification of inflammasomes. This comprehensive review demonstrates the vital role of NLRP3 inflammasome activation in human reproductive diseases together with the underlying mechanisms, offers new insights for mechanistic studies of reproduction, and provides promising possibilities for the development of drugs targeting the NLRP3 inflammasome for the treatment of reproductive disorders in the future.

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人类生殖疾病中的炎症小体。

炎症小体是定位于免疫细胞和非免疫细胞内的多蛋白复合物，可诱导胱天蛋白酶激活、促炎细胞因子分泌，并最终导致细胞死亡。炎症小体与多种人类疾病有关，尤其是急性或慢性炎症性疾病。在这篇综述中，我们重点研究了NLRP3炎症小体与各种生殖疾病之间的强相关性，包括卵巢衰老或卵巢早衰、多囊卵巢综合征、子宫内膜异位症、复发性自然流产、早产、先兆子痫和男性低生育能力，以及NLRP3在这些疾病的发病机制和治疗中的多方面作用。此外，我们还提供了炎症小体的结构和扩增的概述。这篇全面的综述证明了NLRP3炎症小体激活在人类生殖疾病中的重要作用及其潜在机制，为生殖机制研究提供了新的见解，并为未来开发针对NLRP3炎性小体的治疗生殖疾病的药物提供了有希望的可能性。

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来源期刊

Molecular human reproduction 生物-发育生物学

CiteScore

8.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： MHR publishes original research reports, commentaries and reviews on topics in the basic science of reproduction, including: reproductive tract physiology and pathology; gonad function and gametogenesis; fertilization; embryo development; implantation; and pregnancy and parturition. Irrespective of the study subject, research papers should have a mechanistic aspect.