Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma.

Oncoscience Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI:10.18632/oncoscience.587
Mohamed A Gouda, Maria A Zarzour, Ara A Vaporciyan, Kalevi Kairemo, Hubert H Chuang, Vivek Subbiah
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Abstract

Pazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.

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帕唑帕尼在EWSR1-NFATC2易位相关骨肉瘤中的活性。
帕唑帕尼是一种多激酶抑制剂,目前已被批准用于治疗晚期肾细胞癌和化疗难治性软组织肉瘤。在本病例报告中,我们讨论了一名EWSR1-NFATC2融合阳性骨肉瘤患者的病例,该患者通过使用帕唑帕尼和手术获得了特殊的肿瘤控制,总持续时间超过5年。我们还回顾了EWSR1-NFATC2易位相关肉瘤的文献以及帕唑帕尼在骨肉瘤中的应用。
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