Generation of direct current electrical fields as regenerative therapy for spinal cord injury: A review.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL APL Bioengineering Pub Date : 2023-09-19 eCollection Date: 2023-09-01 DOI:10.1063/5.0152669
Lukas Matter, Bruce Harland, Brad Raos, Darren Svirskis, Maria Asplund
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Abstract

Electrical stimulation (ES) shows promise as a therapy to promote recovery and regeneration after spinal cord injury. ES therapy establishes beneficial electric fields (EFs) and has been investigated in numerous studies, which date back nearly a century. In this review, we discuss the various engineering approaches available to generate regenerative EFs through direct current electrical stimulation and very low frequency electrical stimulation. We highlight the electrode-tissue interface, which is important for the appropriate choice of electrode material and stimulator circuitry. We discuss how to best estimate and control the generated field, which is an important measure for comparability of studies. Finally, we assess the methods used in these studies to measure functional recovery after the injury and treatment. This work reviews studies in the field of ES therapy with the goal of supporting decisions regarding best stimulation strategy and recovery assessment for future work.

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直流电场的产生作为脊髓损伤的再生疗法:综述。
电刺激(ES)有望成为促进脊髓损伤后恢复和再生的一种治疗方法。ES疗法建立了有益电场(EF),并在近一个世纪前的许多研究中进行了研究。在这篇综述中,我们讨论了通过直流电刺激和极低频电刺激产生再生EFs的各种工程方法。我们强调了电极-组织界面,这对于适当选择电极材料和刺激器电路非常重要。我们讨论了如何最好地估计和控制生成场,这是衡量研究可比性的重要指标。最后,我们评估了这些研究中用于测量损伤和治疗后功能恢复的方法。这项工作回顾了ES治疗领域的研究,目的是支持关于最佳刺激策略和恢复评估的决策,以供未来工作使用。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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