Dietary linoleic acid intake in relation to breast cancer: A case-control study.

IF 2.4 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Health Promotion Perspectives Pub Date : 2023-09-11 eCollection Date: 2023-01-01 DOI:10.34172/hpp.2023.27

Muhammad Reza Joya, Sina Naghshi, Omid Sadeghi, Sanaz Benisi-Kohansal, Leila Azadbakht, Keyhan Lotfi, Alireza Ostadrahimi, Helda Tutunchi, Ahmad Esmaillzadeh

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Abstract

Background: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women.

Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases in terms of age and socioeconomic status. Dietary intakes were assessed using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (DS-FFQ). Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated.

Results: A significant inverse association was found between LA intake and odds of breast cancer (OR: 0.41, 95% CI: 0.30-0.56). After adjusting for potential confounders, women in the highest tertile of dietary LA intake were 48% less likely to have breast cancer compared with those in the lowest tertile (OR: 0.52, 95% CI: 0.28-0.95). Such a significant inverse association was also seen among normal-weight women (OR: 0.29, 95% CI: 0.14-0.63), and premenopausal women (OR: 0.15, 95% CI: 0.02-0.95).

Conclusion: The findings of current study provide evidence for a protective role of LA against breast cancer particularly among normal-weight and premenopausal women. Prospective studies are needed to confirm this association.

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饮食亚油酸摄入与癌症的关系：一项病例对照研究。

背景：本研究旨在探讨女性饮食亚油酸（LA）摄入量与乳腺癌症的关系。方法：在这项基于人群的病例对照研究中，我们纳入了350例经病理证实的癌症病例和700例对照，这些病例在年龄和社会经济状况方面与病例相匹配。饮食摄入量使用106项威利特格式的半定量菜肴食物频率问卷（DS-FFQ）进行评估。估计了比值比（OR）和相应的95%置信区间（CI）。结果：LA摄入量与癌症发生率呈显著负相关（OR:0.41，95%CI:0.30-0.56），饮食摄入LA最高三分位数的女性患癌症的可能性比最低三分位数女性低48%（OR:0.52，95%CI:0.28-0.95）。在正常体重女性中也发现了这种显著的负相关（OR:0.29，95%CI:0.14-0.63），结论：本研究结果为LA对乳腺癌症的保护作用提供了证据，尤其是在正常体重和绝经前妇女中。需要进行前瞻性研究来证实这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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