Redox signaling-mediated tumor extracellular matrix remodeling: pleiotropic regulatory mechanisms.

IF 4.9 2区 医学 Q2 CELL BIOLOGY Cellular Oncology Pub Date : 2024-04-01 Epub Date: 2023-10-04 DOI:10.1007/s13402-023-00884-9
Guowen Liu, Bowen Li, Siyuan Qin, Edouard C Nice, Jinlin Yang, Li Yang, Canhua Huang
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Abstract

Background: The extracellular matrix (ECM), a fundamental constituent of all tissues and organs, is crucial for shaping the tumor microenvironment. Dysregulation of ECM remodeling has been closely linked to tumor initiation and progression, where specific signaling pathways, including redox signaling, play essential roles. Reactive oxygen species (ROS) are risk factors for carcinogenesis whose excess can facilitate the oxidative damage of biomacromolecules, such as DNA and proteins. Emerging evidence suggests that redox effects can aid the modification, stimulation, and degradation of ECM, thus affecting ECM remodeling. These alterations in both the density and components of the ECM subsequently act as critical drivers for tumorigenesis. In this review, we provide an overview of the functions and primary traits of the ECM, and it delves into our current understanding of how redox reactions participate in ECM remodeling during cancer progression. We also discuss the opportunities and challenges presented by clinical strategies targeting redox-controlled ECM remodeling to overcome cancer.

Conclusions: The redox-mediated ECM remodeling contributes importantly to tumor survival, progression, metastasis, and poor prognosis. A comprehensive investigation of the concrete mechanism of redox-mediated tumor ECM remodeling and the combination usage of redox-targeted drugs with existing treatment means may reveal new therapeutic strategy for future antitumor therapies.

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氧化还原信号介导的肿瘤细胞外基质重塑:多效性调节机制。
背景:细胞外基质(ECM)是所有组织和器官的基本组成部分,对形成肿瘤微环境至关重要。ECM重塑的失调与肿瘤的发生和发展密切相关,其中包括氧化还原信号在内的特定信号通路发挥着重要作用。活性氧(ROS)是致癌的危险因素,其过量可促进生物大分子(如DNA和蛋白质)的氧化损伤。新出现的证据表明,氧化还原效应可以帮助ECM的修饰、刺激和降解,从而影响ECM的重塑。ECM密度和成分的这些变化随后成为肿瘤发生的关键驱动因素。在这篇综述中,我们概述了ECM的功能和主要特征,并深入探讨了我们目前对癌症进展过程中氧化还原反应如何参与ECM重塑的理解。我们还讨论了靶向氧还蛋白控制的ECM重塑以克服癌症的临床策略所带来的机遇和挑战。结论:氧化还原介导的ECM重塑对肿瘤的生存、进展、转移和不良预后有重要影响。全面研究氧化还原介导的肿瘤ECM重塑的具体机制,以及氧化还原靶向药物与现有治疗手段的结合使用,可能会为未来的抗肿瘤治疗揭示新的治疗策略。
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来源期刊
Cellular Oncology
Cellular Oncology ONCOLOGY-CELL BIOLOGY
CiteScore
10.30
自引率
1.50%
发文量
86
审稿时长
12 months
期刊介绍: The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.
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