Efficacy of intravenous alpha lipoic acid in the treatment of neuropatic pain due to carpal tunnel syndrome.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2023-09-30 DOI:10.18071/isz.76.0319

Öztürk Gülsah, Demiryurek Enes Bekir

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Abstract

Background and purpose:

In this study, we analyzed the effect of oral and oral + intravenous Alpha-lipoic acid (ALA) treatment on pain level and physical examination findings in patients diagnosed with carpal tunnel syndrome (CTS).

Methods:

A total of 115 patients patricipated in the study. Physiotherapy and wrist splint were first applied to all patients diagnosed with CTS in the study. 40 patients were treated with oral ALA after iv. ALA therapy, 35 patients received only oral ALA treatment and 40 patients did not receive any medication. The patients were divided into 3 groups as those who received only splint treatment and physiotherapy, those who received oral ALA treatment, and those who received oral ALA treatment after iv. treatment. All patients were assessed before the treatment, and at the 1st and 3rd months of the treatment. In clinical assessment, visual analog scale (VAS) forms were filled to define the pain severity, the Boston symptom severity scale (BSSS) and Boston functional status scale (BFDS) were filled for evaluating symptoms and functional status.

Results:

VAS, BSSS and BFDS scores of the patients who were treated with intravenous and then oral ALA were found to be significantly lower at the end of both the 1st and 3rd months compared to the patients who received only oral ALA or no medication (p=0.001; p<0.001), (p=0.001; p<0.001), (p=0.006; p<0.001).

Conclusion:

We think that iv. ALA is effective in the treatment of symptoms associated with CTS.

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静脉注射α-硫辛酸治疗腕管综合征引起的神经痛的疗效。

背景和目的：在本研究中，我们分析了口服和口服+静脉注射α-硫辛酸（ALA）治疗对腕管综合征（CTS）患者疼痛水平和体检结果的影响。。方法：对115例患者进行回顾性分析；ted在研究中。所有患者首先采用物理疗法和腕夹板治疗；在研究中与CTS一致。40例患者静脉注射后口服ALA；35名患者仅接受口服ALA治疗，40名患者未接受任何药物治疗。将患者分为3组，即仅接受夹板治疗和物理治疗的患者、接受口服ALA治疗的患者和静脉注射后接受口服ALAA治疗的患者；ment。所有患者均被评估为害羞；在治疗前以及在治疗的第1个月和第3个月。在临床评估中，填写视觉模拟量表（VAS）来定义疼痛严重程度，填写波士顿症状严重程度量表（BSSS）和波士顿功能状态量表（BFDS）来评估症状和功能状态；。结果：在第1个月和第3个月结束时，接受静脉注射和口服ALA治疗的患者的VAS、BSSS和BFDS评分均显著低于仅接受口服ALA或未接受药物治疗的患者（p=0.001；p＜0.001）、。ALA可有效治疗CTS相关症状；。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ideggyogyaszati Szemle-Clinical Neuroscience CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Clinical Neuroscience (Ideggyógyászati Szemle) is to provide a forum for the exchange of clinical and scientific information for a multidisciplinary community. The Clinical Neuroscience will be of primary interest to neurologists, neurosurgeons, psychiatrist and clinical specialized psycholigists, neuroradiologists and clinical neurophysiologists, but original works in basic or computer science, epidemiology, pharmacology, etc., relating to the clinical practice with involvement of the central nervous system are also welcome.