Three-year experience with combined complex skin repair in patients with extensive burns: a retrospective study.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2023-09-01

Xingxin Gao, Min Zhang, Dezhi Song, Jialing Wei, Yuan Lin, Yajun Wu, Chaoyi Zhong, Dehui Li, Bangde Xiang

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Abstract

Introduction: The Meek micrografting technique used in STSG expansion is effective in achieving wide and rapid coverage of burn wounds. Certain growth factors have also been shown to modulate or mediate wound healing.

Objective: In this study, a combined treatment approach for severe burns involving the Meek micrografting technique, systemic application of rhGH, and topical application of rhEGF was evaluated.

Materials and methods: A retrospective study was conducted of 7 extensively burned patients who were treated with the Meek technique, systemic application of rhGH, and topical application of rhEGF between January 2017 and December 2019.

Results: The mean percent TBSA burned was 89%. An average of 9.5 surgical procedures were performed to obtain skin cover, with an average of 5.8 Meek micrograft procedures performed in the 6 surviving patients. Complete wound healing was achieved at an average of 120 days in the 6 surviving patients. The mean graft take rate was 81%. Infection was the main reason for graft failure. Donor sites were used for up to 5 re-harvestings without additional morbidity.

Conclusions: A multipronged treatment approach that combines the Meek micrografting technique, systemic application of rhGH, and topical application of rhEGF is a promising tool for the management of severe and extensive burns.

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大面积烧伤患者联合复杂皮肤修复的三年经验：一项回顾性研究。

简介：Meek微移植物技术用于STSG扩张，可有效实现烧伤创面的广泛快速覆盖。某些生长因子也已被证明可以调节或介导伤口愈合。目的：本研究评估了Meek微移植物技术、rhGH全身应用和rhEGF局部应用联合治疗严重烧伤的方法。材料和方法：对2017年1月至2019年12月期间接受Meek技术、rhGH全身应用和rhEGF局部应用治疗的7名大面积烧伤患者进行了回顾性研究。结果：TBSA烧伤的平均百分比为89%。平均进行了9.5次手术来获得皮肤覆盖，6名幸存患者平均进行了5.8 Meek微克手术。6名存活患者的伤口平均在120天内完全愈合。平均移植物接受率为81%。感染是移植失败的主要原因。在没有额外发病率的情况下，供体位点被用于多达5次的再收获。结论：Meek微移植技术、rhGH的全身应用和rhEGF的局部应用相结合的多管齐下治疗方法是治疗严重和大面积烧伤的一种很有前途的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.