{"title":"Rheumatic Heart Disease in East Africa: A Systematic Review and Meta-Analysis.","authors":"Guesh Mebrahtom, Abrha Hailay, Woldu Aberhe, Kidane Zereabruk, Teklehaimanot Haile","doi":"10.1155/2023/8834443","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite being a grave problem, there is little information on rheumatic heart disease's prevalence in East Africa. Therefore, the purpose of this systematic review and meta-analysis was to estimate the pooled prevalence of rheumatic heart disease in East Africa.</p><p><strong>Materials and methods: </strong>A computerized systematic search of using multiple database searching engines was performed in search of relevant English articles from the inception of the databases to December 2019. It was done in accordance with the preferred reporting items for systematic review and meta-analysis (PRISMA) standard. The funnel plot was used to assess publication bias. R and RStudio for Windows were used for all statistical analysis. The random-effect model was used for calculating the pooled estimate of the prevalence of rheumatic heart disease.</p><p><strong>Results: </strong>The database search retrieved 1073 papers, and 80 articles (78 cross-sectional and two cohort study designs) with a total of 184575 individuals were found to be appropriate for the review. In East Africa, the overall prevalence of rheumatic heart disease was 14.67% (95% CI: 13.99% to 15.35%). In Ethiopia, Uganda, Tanzania, and Sudan, respectively, the subgroup analysis of rheumatic heart disease pooled prevalence was 22% (95% CI: 13% to 36%), 11% (95%t CI: 5% to 20%), 9% (95%t CI: 5% to 16%), and 3% (95%t CI: 1% to 10%), while the pooled prevalence of rheumatic heart disease in adults was 20% (95% CI: 12% to 30%), and in children, it was 4% (95% CI: 2% to 8%).</p><p><strong>Conclusions: </strong>From this report, the prevalence of rheumatic heart disease in East Africa is very high, affecting about one in seven people. Therefore, future strategies should emphasize preventive measures at appropriate times to minimize the burden of this type of preventable heart disease.</p>","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522432/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/8834443","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Despite being a grave problem, there is little information on rheumatic heart disease's prevalence in East Africa. Therefore, the purpose of this systematic review and meta-analysis was to estimate the pooled prevalence of rheumatic heart disease in East Africa.
Materials and methods: A computerized systematic search of using multiple database searching engines was performed in search of relevant English articles from the inception of the databases to December 2019. It was done in accordance with the preferred reporting items for systematic review and meta-analysis (PRISMA) standard. The funnel plot was used to assess publication bias. R and RStudio for Windows were used for all statistical analysis. The random-effect model was used for calculating the pooled estimate of the prevalence of rheumatic heart disease.
Results: The database search retrieved 1073 papers, and 80 articles (78 cross-sectional and two cohort study designs) with a total of 184575 individuals were found to be appropriate for the review. In East Africa, the overall prevalence of rheumatic heart disease was 14.67% (95% CI: 13.99% to 15.35%). In Ethiopia, Uganda, Tanzania, and Sudan, respectively, the subgroup analysis of rheumatic heart disease pooled prevalence was 22% (95% CI: 13% to 36%), 11% (95%t CI: 5% to 20%), 9% (95%t CI: 5% to 16%), and 3% (95%t CI: 1% to 10%), while the pooled prevalence of rheumatic heart disease in adults was 20% (95% CI: 12% to 30%), and in children, it was 4% (95% CI: 2% to 8%).
Conclusions: From this report, the prevalence of rheumatic heart disease in East Africa is very high, affecting about one in seven people. Therefore, future strategies should emphasize preventive measures at appropriate times to minimize the burden of this type of preventable heart disease.
背景:尽管这是一个严重的问题,但关于风湿性心脏病在东非的流行情况的信息很少。因此,本系统综述和荟萃分析的目的是估计东非风湿性心脏病的合并患病率。材料和方法:从数据库建立到2019年12月,使用多个数据库搜索引擎进行计算机化系统搜索,搜索相关英文文章。这是根据系统综述和荟萃分析(PRISMA)标准的首选报告项目进行的。漏斗图用于评估发表偏倚。R和RStudio for Windows用于所有统计分析。随机效应模型用于计算风湿性心脏病患病率的汇总估计。结果:数据库搜索检索了1073篇论文,发现80篇文章(78篇横断面和两个队列研究设计)适合进行审查,共184575人。在东非,风湿性心脏病的总患病率为14.67%(95%CI:13.99%-15.35%)。在埃塞俄比亚、乌干达、坦桑尼亚和苏丹,风湿性心病合并患病率的亚组分析分别为22%(95%CI:13%-36%)、11%(95%CI:5%-20%)、9%(95%CI:5%至16%)和3%(95%CI:1%至10%),而成人风湿性心脏病的合并患病率为20%(95%CI:12%-30%),儿童为4%(95%CI:2%-8%)。因此,未来的战略应该强调在适当的时候采取预防措施,以最大限度地减少这种可预防的心脏病的负担。