The epidemiology of pituitary adenomas in a community-based hospital: a retrospective single center study in Saudi Arabia.

Annals of Saudi medicine Pub Date : 2016-09-01 DOI:10.5144/0256-4947.2016.341

Khalid S Aljabri, Samia A Bokhari, Faisal Y Assiri, Muneera A Alshareef, Patan M Khan

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引用次数: 17

Abstract

Background: Data on pituitary adenoma (PA) prevalence in Saudi Arabia are scarce.

Objective: To estimate the epidemiology of PA in a well-defined population.

Design: Retrospective analysis.

Setting: Departments of Endocrinology and Radiology at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.

Patients and methods: Radiological and hormonal data of patients with pituitary adenoma by MRI were reviewed for the period January 2008 to December 2015.

Main outcome measures: Prevalence of PA and hormonal abnormalities.

Results: Of 537 patients; 249 subjects (46.4%), 70 (28.1%) males and 179 (71.9%) females, were diagnosed to have PA with mean age 36.3 (14.1) years. Microadenoma and macroadenoma were seen in 171 (69%) and 78 (31%) subjects, respectively. Microadenomas were more prevalent than macroadenomas (68.7% vs. 31.3%). Microadenomas were significantly more prevalent in females, 131 (73.2 %) vs. 40 (57.1%) whereas macroadenomas were significantly more prevalent in males, 30 (42.9%) vs. 48 (26.8%) (P < .001 for both comparisons). Patients with microadenomas were significantly younger than patients with macroadenomas (P < .0001). Advanced age was significantly associated with a larger PA size (r=0.39, P < .0002). Three types of hyperfunctioning PA were seen: prolactinoma, somatotroph adenoma, and corticotroph adenoma. Five types of hypofunctioning PA were seen: panhypopituitarism, secondary hypogonadism, growth hormone deficiency, central hypothroidism and central adrenal insufficiency. Non-functioning PA were within normal laboratory hormonal values in 2% of cases.

Conclusion: Our study showed that the prevalence of PA was greater than previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of PA.

Limitations: Clustering of cases within the study region might have affected estimates and limited study sample size.

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社区医院垂体腺瘤的流行病学：沙特阿拉伯一项回顾性单中心研究。

背景：关于沙特阿拉伯垂体腺瘤（PA）患病率的数据很少。目的：评估明确人群中PA的流行病学。设计：回顾性分析。背景：沙特阿拉伯吉达法赫德国王武装部队医院内分泌科和放射科。患者和方法：回顾2008年1月至2015年12月期间垂体腺瘤MRI患者的放射学和激素数据。主要结果指标：PA患病率和激素异常。结果：537例患者中；249名受试者（46.4%），70名（28.1%）男性和179名（71.9%）女性被诊断为PA，平均年龄36.3（14.1）岁。微腺瘤和大腺瘤分别见于171例（69%）和78例（31%）受试者。微腺瘤比大腺瘤更常见（68.7%对31.3%）。微腺瘤在女性中更常见，131例（73.2%）对40例（57.1%），而大腺瘤在男性中更普遍，30例（42.9%）对48例（26.8%）（两项比较均P＜0.001）。微腺瘤患者明显比大腺瘤患者年轻（P<.0001）。高龄与较大的PA大小显著相关（r=0.39，P<.0002）。可见三种类型的功能亢进PA：泌乳素瘤、生长激素腺瘤和皮质类固醇腺瘤。有五种类型的功能低下的PA：全垂体功能减退症、继发性性腺功能低下症、生长激素缺乏症、中枢性低血压和中枢性肾上腺功能不全。在2%的病例中，功能不全的PA在正常的实验室激素值范围内。结论：我们的研究表明PA的患病率比以前报道的要高。当优先考虑PA的研究和治疗资金时，这种患病率的增加可能会产生重要影响。局限性：研究区域内病例的聚集可能会影响估计值和有限的研究样本量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Saudi medicine

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