Segmented, Negative-Sense RNA Viruses of Humans: Genetic Systems and Experimental Uses of Reporter Strains.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2023-09-29 DOI:10.1146/annurev-virology-111821-120445
Cait E Hamele, M Ariel Spurrier, Rebecca A Leonard, Nicholas S Heaton
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Abstract

Negative-stranded RNA viruses are a large group of viruses that encode their genomes in RNA across multiple segments in an orientation antisense to messenger RNA. Their members infect broad ranges of hosts, and there are a number of notable human pathogens. Here, we examine the development of reverse genetic systems as applied to these virus families, emphasizing conserved approaches illustrated by some of the prominent members that cause significant human disease. We also describe the utility of their genetic systems in the development of reporter strains of the viruses and some biological insights made possible by their use. To conclude the review, we highlight some possible future uses of reporter viruses that not only will increase our basic understanding of how these viruses replicate and cause disease but also could inform the development of new approaches to therapeutically intervene.

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人类的分段负义RNA病毒:报告菌株的遗传系统和实验用途。
负链RNA病毒是一大类病毒,它们以信使RNA反义的方向将基因组编码在多个片段的RNA中。它们的成员感染广泛的宿主,还有许多值得注意的人类病原体。在这里,我们研究了应用于这些病毒家族的反向遗传系统的发展,强调了一些导致重大人类疾病的重要成员所展示的保守方法。我们还描述了它们的遗传系统在病毒报告株开发中的作用,以及它们的使用可能带来的一些生物学见解。为了总结这篇综述,我们强调了报告病毒未来可能的一些用途,这些用途不仅将增加我们对这些病毒如何复制和致病的基本了解,还可以为开发新的治疗干预方法提供信息。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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