{"title":"Rare case of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis.","authors":"Hatem Alzahrani, Melanie Pancoast, Kody Finstad, Nicole Pele, Francisca Fasipe, Mohamed Elsaid","doi":"10.1002/ped4.12392","DOIUrl":null,"url":null,"abstract":"Upon hospital admission, the patient had a history of fever and lethargy for 11 days. Further history revealed that his father is a farm worker. Initial physical examination showed massive hepatosplenomegaly. Laboratory testing showed pancytopenia and mild elevation of his liver enzymes with Hb 78 g/L, MCV 80 fl, WBC 1.1 × 109/L, ANC 1.2 × 109/L, and platelet count of 110 × 109/L. Abdominal computer tomography confirmed the hepatosplenomegaly. Additional laboratory tests showed ferritin 830 ng/ml, fibrinogen 1.32 mg/L, triglycerides 2.13 mg/L, soluble interlukin-2 (IL-2) receptor 9560 Units/ml, and negative human immunodeficiency virus (HIV) serology.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/95/PED4-7-222.PMC10509400.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ped4.12392","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Upon hospital admission, the patient had a history of fever and lethargy for 11 days. Further history revealed that his father is a farm worker. Initial physical examination showed massive hepatosplenomegaly. Laboratory testing showed pancytopenia and mild elevation of his liver enzymes with Hb 78 g/L, MCV 80 fl, WBC 1.1 × 109/L, ANC 1.2 × 109/L, and platelet count of 110 × 109/L. Abdominal computer tomography confirmed the hepatosplenomegaly. Additional laboratory tests showed ferritin 830 ng/ml, fibrinogen 1.32 mg/L, triglycerides 2.13 mg/L, soluble interlukin-2 (IL-2) receptor 9560 Units/ml, and negative human immunodeficiency virus (HIV) serology.