Evidence of Altered Fear Extinction Learning in Individuals with High Vaccine Hesitancy During Covid-19 Pandemic.

IF 2 Q3 CLINICAL NEUROLOGY Clinical Neuropsychiatry Pub Date : 2023-08-01 DOI:10.36131/cnfioritieditore20230417

Carmelo M Vicario, Stergios Makris, Laura Culicetto, Chiara Lucifora, Alessandra Falzone, Gabriella Martino, Francesca Ferraioli, Michael A Nitsche, Alessio Avenanti, Giuseppe Craparo

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Abstract

Objective: A relevance of fear and concerns about vaccine development and its side effects are suggested to explain COVID-19 vaccine hesitancy. However, evidence supporting the phobic origin hypothesis of hesitancy for COVID-19 and other vaccinations remains indirect and elusive.

Method: We addressed this issue by investigating the existence of a relationship between fear conditioning, extinction, and the respective vaccination hesitancy and anxiety scores in a group of 25 individuals.

Results: Overall, we show that the general mechanism of fear extinction learning is impaired in individuals with high vaccine hesitancy. State and trait anxiety scores do not account for this result.

Conclusions: These findings suggest that attitudes against vaccination could be linked to an altered inhibitory learning process.

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新冠肺炎大流行期间疫苗犹豫程度高的个体恐惧消失学习改变的证据。

目的：提出对疫苗开发及其副作用的恐惧和担忧的相关性，以解释新冠肺炎疫苗犹豫。然而，支持对新冠肺炎和其他疫苗接种犹豫不决的恐惧起源假说的证据仍然是间接和难以捉摸的。方法：我们通过调查25名个体的恐惧条件反射、消退与各自的疫苗接种犹豫和焦虑评分之间的关系来解决这个问题。结果：总体而言，我们发现，在疫苗犹豫程度高的个体中，恐惧消退学习的一般机制受到了损害。状态和特质焦虑评分并不能解释这个结果。结论：这些发现表明，反对接种疫苗的态度可能与抑制性学习过程的改变有关。

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来源期刊

Clinical Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

11.10

自引率

1.60%

发文量