Emergence of SARS-CoV-2 variant of interest B.1.525 (Eta) in Bangladesh

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-05 DOI:10.1016/j.biologicals.2023.101714

Barna Goswami , Md Murshed Hasan Sarkar , Shahina Akter , Tanjina Akhtar Banu , Iffat Jahan , Md Saddam Hossain , Mohammad Mohi Uddin , Tasnim Nafisa , Md Maruf Ahmed Molla , Mahmuda Yeasmin , Eshrar Osman , Mohammad Samir Uzzaman , Abu Sayeed Mohammad Mahmud , Ahashan Habib , Salim Khan

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Abstract

In the present study, we report the complete genome of five Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Bangladesh harboring mutations at Spike protein (E484K, Q677H, D614G, A67V, Q52R, Y144del, H69del, V70del, F888L) assigned to the B.1.525 lineage (Variant of interest). Mutations are also found in viral structural proteins other than spike region (E_L21F, M_I82F, N_A12G and N_T208I) and other mutations (NSP3_T1189I, NSP6_S106del, NSP6_F108del, NSP6_G107del, NSP12_P323F) from all of five B.1.525 SARS-CoV-2 variants of Bangladesh. We have also found four unique mutations from two of SARS-CoV-2 B.1.525 variant of Bangladesh. Among the four unique mutations two mutations (NS7a_L96H, NS7a_Y97D) obtained from strain BCSIR-NILMRC-718, one (NSP3_A1430V) from BCSIR-NILMRC-738 and two mutation including one spike protein mutation (NSP2_L444I, Spike_I68 M) present in BCSIR-AFIP-10 strain. The identification of new mutations will contribute to characterizing SARS-CoV-2, to continue tracking its spread and better understanding its biological and clinical features to take medical countermeasures and vaccines.

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孟加拉国出现感兴趣的严重急性呼吸系统综合征冠状病毒2型变种B.1.525（Eta）。

在本研究中，我们报道了来自孟加拉国的五种严重急性呼吸综合征冠状病毒2型（严重急性呼吸系统综合征冠状病毒-2）的完整基因组，这些病毒在刺突蛋白（E484K、Q677H、D614G、A67V、Q52R、Y144del、H69del、V70del、F888L）上具有突变，属于B.1.525谱系（感兴趣的变体）。在除刺突区（E_L21F、M_I82F、N_A12G和N_T208I）和来自孟加拉国所有五种B.1.525严重急性呼吸系统综合征冠状病毒2型变体的其他突变（NSP3_T1189I、NSP6_S106del、NSP6_F108del、NSP6GG107del、NSP12_P323F）之外的病毒结构蛋白中也发现了突变。我们还从孟加拉国的两种严重急性呼吸系统综合征冠状病毒2型B.1.525变种中发现了四种独特的突变。在四个独特突变中，两个突变（NS7a_L96H，NS7a_Y97D）来自菌株BCSIR-NILMRC-718，一个突变（NSP3_A1430V）来自BCSIR-NILMRC-738，以及两个突变，包括BCSIR-AFIP-10菌株中存在的一个刺突蛋白突变（NSP2_L444I，spike_I68M）。新突变的识别将有助于表征严重急性呼吸系统综合征冠状病毒2型，继续追踪其传播，更好地了解其生物学和临床特征，以采取医疗对策和疫苗。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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