ABO blood group and rhesus factor association with inpatient COVID-19 mortality and severity: a two-year retrospective review.

IF 2.3 Q2 HEMATOLOGY Blood Research Pub Date : 2023-09-30 DOI:10.5045/br.2023.2023122
Alexander T Phan, Ari A Ucar, Aldin Malkoc, Janie Hu, Luke Buxton, Alan W Tseng, Fanglong Dong, Julie P T Nguyễn, Arnav P Modi, Ojas Deshpande, Johnson Lay, Andrew Ku, Dotun Ogunyemi, Sarkis Arabian
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Abstract

Background: Early reports have indicated a relationship between ABO and rhesus blood group types and infection with SARS-CoV-2. We aim to examine blood group type associations with COVID-19 mortality and disease severity.

Methods: This is a retrospective chart review of patients ages 18 years or older admitted to the hospital with COVID-19 between January 2020 and December 2021. The primary outcome was COVID-19 mortality with respect to ABO blood group type. The secondary outcomes were 1. Severity of COVID-19 with respect to ABO blood group type, and 2. Rhesus factor association with COVID-19 mortality and disease severity. Disease severity was defined by degree of supplemental oxygen requirements (ambient air, low-flow, high-flow, non-invasive mechanical ventilation, and invasive mechanical ventilation).

Results: The blood type was collected on 596 patients with more than half (54%, N=322) being O+. The ABO blood type alone was not statistically associated with mortality (P=0.405), while the RH blood type was statistically associated with mortality (P<0.001). There was statistically significant association between combined ABO and RH blood type and mortality (P=0.014). Out of the mortality group, the O+ group had the highest mortality (52.3%), followed by A+ (22.8%). The combined ABO and RH blood type was statistically significantly associated with degree of supplemental oxygen requirements (P=0.005). The Kaplan-Meier curve demonstrated that Rh- patients had increased mortality.

Conclusion: ABO blood type is not associated with COVID-19 severity and mortality. Rhesus factor status is associated with COVID-19 severity and mortality. Rhesus negative patients were associated with increased mortality risk.

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ABO血型和恒河猴因子与住院新冠肺炎死亡率和严重程度的相关性:一项为期两年的回顾性审查。
背景:早期报告表明ABO血型和恒河猴血型与严重急性呼吸系统综合征冠状病毒2型感染之间存在关系。我们的目的是检查血型与新冠肺炎死亡率和疾病严重程度的关系。方法:这是对2020年1月至2021年12月期间因新冠肺炎入院的18岁或18岁以上患者的回顾性图表回顾。主要结果是新冠肺炎ABO血型死亡率。次要结果为1。新冠肺炎与ABO血型相关的严重程度,以及2。恒河猴因子与新冠肺炎死亡率和疾病严重程度的关系。疾病的严重程度由补充氧气的程度(环境空气、低流量、高流量、无创机械通气和有创机械通气)来定义。结果:收集了596名患者的血型,其中超过一半(54%,N=322)为O+。仅ABO血型与死亡率无统计学相关性(P=0.405),而RH血型与死亡率有统计学相关性(PP=0.014)。在死亡率组中,O+组的死亡率最高(52.3%),其次是A+(22.8%)。ABO和RH的联合血型与补充氧气的程度有统计学意义(P=0.005)。Kaplan-Meier曲线表明RH患者的死亡率增加。结论:ABO血型与新冠肺炎的严重程度和死亡率无关。恒河猴因子状态与新冠肺炎的严重程度和死亡率相关。恒河猴阴性患者的死亡率增加。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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