Serum anti-Müllerian hormone concentrations are related to embryo development: lessons from time-lapse imaging.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI:10.1017/S0967199423000370

Amanda Souza Setti, Daniela Paes de Almeida Ferreira Braga, Patricia Guilherme, Assumpto Iaconelli, Edson Borges

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Abstract

Our objective was to study whether serum anti-Müllerian hormone (AMH) concentrations were associated with embryo morphokinetic events. This retrospective cohort study was performed in a private university-affiliated in vitro fertilization centre between March 2019 and December 2020 and included 902 oocytes cultured in a time-lapse imaging incubator, obtained from 114 intracytoplasmic sperm injection cycles performed. The relationship between AMH concentrations and morphokinetic events was investigated by considering the clustering of data (multiple embryos/patient). Evaluated kinetic markers were time to pronuclei appearance (tPNa) and fading (tPNf), time to two (t2), three (t3), four (t4), five (t5), six (t6), seven (t7), and eight cells (t8), (tSB) and time to the start of blastulation (tSB) and to blastulation (tB). Significant inverse relationships were observed between serum AMH concentrations and tPNf, t3, t4, t5, t6, t7, t8, and tB. The AMH was positively correlated with the KIDScore and implantation rate. Increased serum AMH concentrations correlated with faster embryo development. The clinical implications of this effect on embryo development warrant further investigation.

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血清抗米勒激素浓度与胚胎发育有关：延时成像的经验教训。

我们的目的是研究血清抗米勒激素（AMH）浓度是否与胚胎形态动力学事件有关。这项回顾性队列研究于2019年3月至2020年12月在一所私立大学附属体外受精中心进行，包括902个在延时成像培养箱中培养的卵母细胞，这些卵母细胞是从114个细胞质内精子注射周期中获得的。通过考虑数据聚类（多个胚胎/患者），研究AMH浓度与形态动力学事件之间的关系。评估的动力学标志物是到原核出现的时间（tPNa）和消退的时间（tPNf）、到两个细胞的时间（t2）、三个细胞的（t3）、四个细胞的距离（t4）、五个细胞的间隔（t5）、六个细胞的距离（t6）、七个细胞的离（t7）和八个细胞的间距（t8）、（tSB。在血清AMH浓度与tPNf、t3、t4、t5、t6、t7、t8和tB之间观察到显著的反比关系。AMH与KIDScore和植入率呈正相关。血清AMH浓度升高与胚胎发育加快相关。这种影响对胚胎发育的临床意义值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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