[Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis].

N A Lunina, D R Safina, S V Kostrov
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引用次数: 0

Abstract

Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute to tumor growth, invasion, metastasis, and resistance to therapy. However, clinical trials of treatment strategies targeting CAFs have largely failed. Moreover, there is evidence that CAFs are capable of inhibiting tumor development. The review considers the current data on the functional heterogeneity of CAFs and their bimodality in tumor development and progression. Understanding the tumor-promoting and tumor-inhibiting activities of CAFs can help to develop new diagnostic and therapeutic approaches.

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[癌症相关成纤维细胞:肿瘤发生中的异质性和双模态]。
癌症相关成纤维细胞(CAFs)通常形成肿瘤微环境(TMA)的主要组成部分,为癌症细胞的生长提供条件。CAFs可能有助于肿瘤生长、侵袭、转移和对治疗的抵抗。然而,针对CAFs的治疗策略的临床试验在很大程度上失败了。此外,有证据表明CAFs能够抑制肿瘤的发展。这篇综述考虑了目前关于CAFs功能异质性及其在肿瘤发展和进展中的双峰性的数据。了解CAFs的促瘤和抑瘤活性有助于开发新的诊断和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molekulyarnaya Biologiya
Molekulyarnaya Biologiya Medicine-Medicine (all)
CiteScore
0.70
自引率
0.00%
发文量
131
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