Efficacy of single-and double-volume exchange transfusion for neonatal hyperbilirubinemia.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI:10.5937/jomb0-42668

Zhongzheng Xiong, Xianchuan Liu, Xiangzhu Li

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Abstract

Background: To investigate the efficacy and safety of singleand double-volume exchange transfusion for neonatal hyperbilirubinemia (HB) and compare their effects on the internal environment of newborns.

Methods: The clinical data of 96 HB newborns admitted to and treated in our hospitals from January 2016 to October 2021 were retrospectively analyzed. Then, these newborns were divided into single volume group (80-110 mL/kg, n=48) and double volume group (150-180 mL/kg, n=48) by the exchange volume per unit body mass. The hematological indicators total serum bilirubin (TSB), peripheral blood red blood cell (RBC) count, white blood cell (WBC) count, platelet (PLT) count, serum albumin (ALB), prothrombin time (PT) and activated partial thromboplastin time (APTT), and changes in inner-environment indexes (blood gas, blood glucose, acid-base and electrolyte levels) were compared between the two groups of newborns before treatment and after once treatment. Additionally, the adverse reactions of exchange transfusion in the two groups of newborns were recorded.

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单、双容量换血治疗新生儿高胆红素血症的疗效观察。

背景：探讨单、双容量换血治疗新生儿高胆红素血症（HB）的疗效和安全性，并比较其对新生儿内环境的影响。方法：对2016年1月至2021年10月我院收治的96例HB新生儿的临床资料进行回顾性分析。然后，按单位体重交换量将新生儿分为单容量组（80～110 mL/kg，n=48）和双容量组（150～180 mL/kg，n=48）。血液学指标血清总胆红素（TSB）、外周血红细胞（RBC）计数、白细胞（WBC）计数、血小板（PLT）计数、血清白蛋白（ALB），比较两组新生儿治疗前后凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）及内环境指标（血气、血糖、酸碱和电解质水平）的变化。此外，还记录了两组新生儿的换血不良反应。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.