{"title":"The Role of TRIM24 in Allergic Rhinitis.","authors":"Seung Koo Yang, Doo Hee Han","doi":"10.4168/aair.2023.15.5.543","DOIUrl":null,"url":null,"abstract":"https://e-aair.org Allergic rhinitis (AR) is a common inflammatory disease characterized by rhinorrhea, nasal obstruction, sneezing, and itchy nose. The inflammation of nasal mucosa is ultimately caused by an exposure to allergens and immunoglobulin (Ig) E-mediated sensitization, in which T helper type 2 (Th2) cells and cytokines—interleukin (IL)-4, IL-5, and IL-13—play an important role.1,2 IL-4 is crucial in activating Janus kinase (JAK), which phosphorylates transcription factor, signal transducer and activator of transcription 6 (STAT6), a key factor for Th2 polarization.3,4 On the other hand, tripartite motif-containing 24 (TRIM24), promotes STAT6 acetylation by catalyzing the ubiquitination of cAMP-responsive elementbinding protein (CREB)-binding protein at Lys 119.5 Previous studies have proposed the role of TRIM24 in other diseases, such as head and neck squamous cell carcinoma,6 prostate cancer,7 and breast cancer.8 However, its role in AR has not been explored.","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"543-544"},"PeriodicalIF":4.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/cf/aair-15-543.PMC10570779.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergy, Asthma & Immunology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4168/aair.2023.15.5.543","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
https://e-aair.org Allergic rhinitis (AR) is a common inflammatory disease characterized by rhinorrhea, nasal obstruction, sneezing, and itchy nose. The inflammation of nasal mucosa is ultimately caused by an exposure to allergens and immunoglobulin (Ig) E-mediated sensitization, in which T helper type 2 (Th2) cells and cytokines—interleukin (IL)-4, IL-5, and IL-13—play an important role.1,2 IL-4 is crucial in activating Janus kinase (JAK), which phosphorylates transcription factor, signal transducer and activator of transcription 6 (STAT6), a key factor for Th2 polarization.3,4 On the other hand, tripartite motif-containing 24 (TRIM24), promotes STAT6 acetylation by catalyzing the ubiquitination of cAMP-responsive elementbinding protein (CREB)-binding protein at Lys 119.5 Previous studies have proposed the role of TRIM24 in other diseases, such as head and neck squamous cell carcinoma,6 prostate cancer,7 and breast cancer.8 However, its role in AR has not been explored.
期刊介绍：
The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.
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