Early-immune development in asthma: A review of the literature

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2023-09-28 DOI:10.1016/j.cellimm.2023.104770
Maria V. Medeleanu , Yu Chen Qian , Theo J. Moraes , Padmaja Subbarao
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Abstract

This review presents a comprehensive examination of the various factors contributing to the immunopathogenesis of asthma from the prenatal to preschool period. We focus on the contributions of genetic and environmental components as well as the role of the nasal and gut microbiome on immune development. Predisposing genetic factors, including inherited genes associated with increased susceptibility to asthma, are discussed alongside environmental factors such as respiratory viruses and pollutant exposure, which can trigger or exacerbate asthma symptoms. Furthermore, the intricate interplay between the nasal and gut microbiome and the immune system is explored, emphasizing their influence on allergic immune development and response to environmental stimuli. This body of literature underscores the necessity of a comprehensive approach to comprehend and manage asthma, as it emphasizes the interactions of multiple factors in immune development and disease progression.

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哮喘的早期免疫发展:文献综述。
本文综述了从产前到学龄前哮喘免疫发病的各种因素。我们关注基因和环境成分的贡献,以及鼻腔和肠道微生物组在免疫发育中的作用。易感遗传因素,包括与哮喘易感性增加相关的遗传基因,与环境因素(如呼吸道病毒和污染物暴露)一起讨论,这些因素可能引发或加剧哮喘症状。此外,还探讨了鼻腔和肠道微生物组与免疫系统之间复杂的相互作用,强调了它们对过敏性免疫发育和对环境刺激的反应的影响。这一系列文献强调了理解和管理哮喘的全面方法的必要性,因为它强调了免疫发展和疾病进展中多种因素的相互作用。
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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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