REM Behavior Disorder: Implications for PD Therapeutics.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2023-11-01 Epub Date: 2023-10-13 DOI:10.1007/s11910-023-01310-1

Jeanne S Feuerstein, Amy Amara

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Abstract

Purpose: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that occurs during REM sleep, characterized by REM sleep without atonia (RSWA) and dream enactment behavior (DEB). RBD is associated with several diseases and medications but most notably is a prodromal feature of synucleinopathies, including Parkinson's disease (PD). This article reviews RBD, its treatments, and implications for PD therapeutics.

Recent findings: Recent research recognizes RBD as a prodromal marker of PD, resulting in expansion of basic science and clinical investigations of RBD. Current basic science research investigates the pathophysiology of RBD and explores animal models to allow therapeutic development. Clinical research has focused on natural history observation, as well as potential RBD treatments and their impact on sleep and phenoconversion to neurodegenerative disease. RBD serves as a fresh access point to develop both neuroprotective and symptomatic therapies in PD. These types of investigations are novel and will benefit from the more established basic science infrastructure to develop new interventions.

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快速眼动行为障碍：对帕金森病治疗的启示。

目的：快速眼动（REM）睡眠行为障碍（RBD）是发生在快速眼动睡眠期间的一种准睡眠障碍，其特征是快速眼动睡眠无张力（RSWA）和做梦行为（DEB）。RBD与几种疾病和药物有关，但最值得注意的是，它是包括帕金森病（PD）在内的突触核蛋白病的前驱特征。本文综述RBD，它的治疗，以及对PD治疗的启示。最近的发现：最近的研究承认RBD是PD的前驱标志物，从而扩大了RBD的基础科学和临床研究。目前的基础科学研究调查了RBD的病理生理学，并探索了允许治疗发展的动物模型。临床研究的重点是自然史观察，以及潜在的RBD治疗方法及其对睡眠和表型转化为神经退行性疾病的影响。RBD是开发帕金森病神经保护和症状疗法的新途径。这些类型的研究是新颖的，将受益于更成熟的基础科学基础设施，以开发新的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.