Recovery Capital Gains May Precede Craving Reduction in Opioid Use Disorder.

IF 5.1 Q1 SUBSTANCE ABUSE Substance Abuse and Rehabilitation Pub Date : 2023-10-05 eCollection Date: 2023-01-01 DOI:10.2147/SAR.S433350
Nicholas L Bormann, Andrea N Weber, Benjamin Miskle, Stephan Arndt, Alison C Lynch
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Abstract

Purpose: Cravings for drugs and alcohol have been significantly associated with worse treatment outcomes. We investigated if improvements in recovery capital (RC) (eg, a measure of social capital/network, financial resources, education, and cultural factors) over time were associated with decreased reported cravings.

Patients and methods: The original cohort consisted of 133 participants (63 females) with opioid use disorder seeking outpatient treatment, who completed the Assessment of Recovery Capital (ARC) (range 0 to 50) and the Brief Addiction Monitor (BAM) thrice over the 6-month study. Intervention was medication and case management. Analysis included one-way mixed models testing change over time for ARC total scores and single question craving rating (5-point Likert scale). Cross-lagged panel estimates used structural equation models with variables z-scored, allowing for path coefficient evaluation as standard deviations (sd).

Results: Total ARC significantly increased over the study (χ2 = 33.77, df = 2, p < 0.0001), with baseline of 36.6 (n = 114, sd = 11.1) and 6-month of 41.2 (n = 107, sd = 9.5). Craving also changed significantly (χ2 = 8.51, df = 2, p < 0.015), with baseline of 1.1 (n = 101, sd = 1.2) and 6-month of 0.9 (n = 107, sd = 1.1). The cross-lag from baseline RC to 3-month craving was significant (β = -0.28, SE = 0.11, z = -2.53, p < 0.011). The converse was not true; baseline craving did not affect later RC. Results were similarly significant when comparing 3-month to 6-month. The majority of sample was on buprenorphine.

Conclusion: As RC improves, the reported cravings at both 3- and 6-month study time points are significantly reduced. When evaluated inversely, there was not a significant association with baseline cravings and follow-up RC. Significant path coefficients provide an estimation of a directional effect from increased RC towards craving reduction.

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恢复资本收益可能先于阿片类药物使用障碍的迫切减少。
目的:渴望药物和酒精与较差的治疗结果显著相关。我们调查了随着时间的推移,恢复资本(RC)(如社会资本/网络、财政资源、教育和文化因素的衡量标准)的改善是否与报告的渴望减少有关。患者和方法:最初的队列由133名患有阿片类药物使用障碍寻求门诊治疗的参与者(63名女性)组成,他们在6个月的研究中三次完成了恢复资本评估(ARC)(范围为0-50)和短暂成瘾监测(BAM)。干预是药物治疗和病例管理。分析包括单向混合模型,测试ARC总分和单题渴望评级(5分Likert量表)随时间的变化。交叉滞后面板估计使用了变量为z的结构方程模型,允许将路径系数评估为标准差(sd)。结果:总ARC在研究期间显著增加(χ2=33.77,df=2,p<0.01),基线为36.6(n=114,sd=11.1),6个月为41.2(n=107,sd=9.5),基线为1.1(n=101,sd=1.2),6个月为0.9(n=107,sd=1.1)。从基线RC到3个月渴望的交叉滞后显著(β=0.28,SE=0.11,z=2.53,p<0.01)。相反;基线渴求不影响后期RC。当比较3个月和6个月时,结果同样显著。大部分样本是丁丙诺啡。结论:随着RC的改善,报告的3个月和6个月研究时间点的食欲都显著降低。当反向评估时,与基线食欲和随访RC没有显著关联。显著路径系数提供了从增加的RC到减少渴望的方向效应的估计。
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