Flow-mediated dilation as a marker of endothelial dysfunction in pulmonary diseases: A narrative review

IF 2.2 4区医学 Q3 RESPIRATORY SYSTEM Respiratory Medicine and Research Pub Date : 2023-09-16 DOI:10.1016/j.resmer.2023.101049

Lucia Abagnale , Claudio Candia , Andrea Motta , Brurya Galloway , Pasquale Ambrosino , Antonio Molino , Mauro Maniscalco

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Abstract

The endothelium is an active and crucial component of vessels and produces several key regulatory factors for the homeostasis of the entire organism. Endothelial function can be investigated invasively or non-invasively, both in the coronary and peripheral circulation. A widely accepted method for the assessment of endothelial function is measurement of flow-mediated dilation (FMD), which evaluates the vascular response to changes in blood flow.

In this current review, we describe FMD applications in the clinical setting of different respiratory diseases: acute SARS-COV2 infection, pulmonary embolism; post-acute SARS-COV2 infection, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apneas Syndrome, Pulmonary Hypertension, Interstitial Lung Diseases.

Emerging evidence shows that FMD might be an effective tool to assess the cardiovascular risk in patients suffering from the undermentioned respiratory diseases as well as an independent predictive factor of disease severity and/or recovery.

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流动介导的扩张作为肺部疾病内皮功能障碍的标志：叙述性综述。

内皮是血管的一个活跃而重要的组成部分，并为整个生物体的稳态产生几个关键的调节因子。内皮功能可以在冠状动脉和外周循环中进行有创或无创研究。一种广泛接受的评估内皮功能的方法是测量流介导的扩张（FMD），它评估血管对血流变化的反应。在这篇最新的综述中，我们描述了FMD在不同呼吸道疾病的临床应用：急性严重急性呼吸系统综合征冠状病毒2型感染、肺栓塞；急性严重急性呼吸系统综合征冠状病毒2型感染后、慢性阻塞性肺病、阻塞性睡眠呼吸暂停综合征、肺动脉高压、间质性肺病。新出现的证据表明，FMD可能是评估以下呼吸道疾病患者心血管风险的有效工具，也是疾病严重程度和/或康复的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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